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lychnopholide

isolated from Vanillosmopsis erythropappa; structure in first source

Networked: 6 relevant articles (2 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - lychnopholide: 6
- Lactones: 1549
  - lychnopholide: 6

Experts

1.	Saúde-Guimarães, Dênia Antunes: 4 articles (04/2021 - 01/2016)
2.	Mosqueira, Vanessa Carla Furtado: 4 articles (01/2020 - 01/2016)
3.	Branquinho, Renata Tupinambá: 3 articles (01/2020 - 01/2016)
4.	de Lana, Marta: 3 articles (01/2020 - 01/2017)
5.	Oliveira, Maykon Tavares: 2 articles (01/2020 - 01/2016)
6.	de Mello, Carlos Geraldo Campos: 2 articles (01/2020 - 01/2016)
7.	Barros, Camila Helena: 1 article (04/2021)
8.	Bernardes, Ana Catharina Fernandes Pereira Ferreira: 1 article (04/2021)
9.	Costa, Daniela Caldeira: 1 article (04/2021)
10.	Matosinhos, Rafaela Cunha: 1 article (04/2021)

Related Diseases

1.	Chagas Disease (American Trypanosomiasis) 01/01/2016 - "Efficacy of Lychnopholide Polymeric Nanocapsules after Oral and Intravenous Administration in Murine Experimental Chagas Disease." 01/01/2017 - "Altogether, our data establish lychnopholide presented in nanocapsule form more firmly as a promising new drug candidate to cure Chagas disease with minimal cardiotoxicity. " 01/01/2017 - "Lychnopholide, a lipophilic sesquiterpene lactone, is efficacious in mice at the acute and chronic phases of Chagas disease. " 01/01/2017 - "The present lychnopholide intravenous dosage form showed great potential for further pre-clinical and clinical studies in Chagas disease and cancer therapies."
2.	Inflammation (Inflammations) 04/06/2021 - "Lychnopholide, eremantholide C, and goyazensolide improved the inflammation induced by MSU crystals by inhibiting the migration of neutrophils to the inflamed area and by blocking the release of the pro-inflammatory cytokine TNF-α. "
3.	Neoplasms (Cancer) 07/01/2016 - "Lychnopholide is a sesquiterpene lactone usually obtained from Lychnophora and Eremanthus species and has pharmacological activities that include anti-inflammatory and anti-tumor. " 01/01/2017 - "The present lychnopholide intravenous dosage form showed great potential for further pre-clinical and clinical studies in Chagas disease and cancer therapies."
4.	Cardiotoxicity 01/01/2017 - "Biodegradable Polymeric Nanocapsules Prevent Cardiotoxicity of Anti-Trypanosomal Lychnopholide." 01/01/2017 - "Altogether, our data establish lychnopholide presented in nanocapsule form more firmly as a promising new drug candidate to cure Chagas disease with minimal cardiotoxicity. "
5.	Infections 01/01/2020 - "Lychnopholide in Poly(d,l-Lactide)-Block-Polyethylene Glycol Nanocapsules Cures Infection with a Drug-Resistant Trypanosoma cruzi Strain at Acute and Chronic Phases."

Related Drugs and Biologics

1.	Nanocapsules
2.	Cytokines
3.	eremantholide C
4.	furanoheliangolide
5.	Dosage Forms (Dosage Form)
6.	Sesquiterpenes
7.	Lactones
8.	Polyethylene Glycols (Polyethylene Glycol)
9.	poly(lactide) (polylactic acid)

Related Therapies and Procedures

1.	Intravenous Administration
2.	Therapeutics