structure in first source
Also Known As:
B-10148; Lys(-1)-Lys(0)-Arg(1)-Pro(2)-Hyp(3)-Gly(4)-Igl(5)-Ser(6)-DF5F(7)-Oic(8); lysyl-lysyl-arginyl-prolyl-4-hydroxyprolyl-glycyl-alpha(2-indanyl)glycyl-seryl-2,3,4,5,6-pentafluorophenylalanyl-octahydroindole-2-carboxylic acid
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Bio-Agent Context: Research Results
|1. ||Tics (Tic)
- "Three peptides, B-10148 (Lys-1-Lys0-Arg1-Pro2-Hyp3-Gly4-Igl5-Ser6- DF5F7-Oic8; where Hyp is trans-4-hydroxyproline, Igl is alpha-(2-indanyl)glycine, F5F is 2,3,4,5,6-pentafluorophenylalanine and Oic is (3aS,7aS)-octahydroindole-2-carboxylic acid), B-10206 (DArg0-Arg1-Pro2-Hyp3-Gly4-Igl5-Ser6-DF 5F7-Nc7G8-Arg9; where Nc7G is N-cycloheptylglycine) and B- 10284 (Arg1-Pro2-Pro3-Gly4-Phe5-Thr6-DTic7-Oic8- NH2; where Tic is 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid), were studied in detail by NMR spectroscopy in 60% CD3OH /40% H2O and modeled by a simulated annealing protocol to determine their solution structure.
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