|1.||Barst, Robyn J: 10 articles (09/2012 - 03/2002)|
|2.||Rubin, Lewis J: 9 articles (09/2013 - 03/2002)|
|3.||Gomberg-Maitland, Mardi: 7 articles (02/2015 - 11/2005)|
|4.||Skoro-Sajer, Nika: 7 articles (12/2012 - 06/2006)|
|5.||Arneson, Carl: 6 articles (09/2013 - 02/2003)|
|6.||Seeger, Werner: 6 articles (10/2011 - 04/2006)|
|7.||Benza, Raymond L: 5 articles (02/2015 - 12/2005)|
|8.||White, R James: 5 articles (09/2013 - 02/2010)|
|9.||Tapson, Victor F: 5 articles (09/2013 - 02/2003)|
|10.||Ivy, D Dunbar: 5 articles (05/2013 - 08/2005)|
|1.||Pulmonary Hypertension (Ayerza Syndrome)
11/01/2006 - "Treprostinil in advanced experimental pulmonary hypertension: beneficial outcome without reversed pulmonary vascular remodeling."
07/01/2012 - "First-line treatment of severe pre-capillary pulmonary hypertension with sub-cutaneous treprostinil is safe and efficacious over many years. "
01/01/2008 - "There are uncontrolled data suggesting efficacy of subcutaneous treprostinil in chronic thromboembolic pulmonary hypertension. "
06/01/2006 - "Efficacy of long-term subcutaneous treprostinil sodium therapy in pulmonary hypertension."
10/17/2006 - "This study sought to investigate the effects of inhaled treprostinil on pulmonary hemodynamics and gas exchange in severe pulmonary hypertension. "
|2.||Dyspnea (Shortness of Breath)
02/01/2010 - "We conclude that treprostinil treatment significantly improved exercise capacity, dyspnea and functional class. "
07/01/2006 - "Patients receiving IV treprostinil at a stable dose were transitioned from their current CADD-Legacy pump to the 407C and were assessed for adverse events including catheter occlusions, pump alarms, and efficacy (six minute walk distance (6MWD), Borg Dyspnea Score (BDS), NYHA functional class, and PAH signs/symptoms). "
03/15/2002 - "Concomitantly, treprostinil significantly improved indices of dyspnea, signs and symptoms of pulmonary hypertension, and hemodynamics. "
08/01/2004 - "Dyspnea fatigue scores also improved in the treprostinil group compared with the placebo group (p = 0.014). "
12/01/2012 - "Improvements in dyspnea fatigue index score (P = .01) and combined 6MWD and Borg dyspnea score (P = .01) were observed with oral treprostinil vs placebo treatment. "
11/01/2010 - "Prospective and observational clinical studies have shown that the dose of SC treprostinil can be escalated at a higher rate than described in early clinical trials to achieve symptom relief, in part because of favorable tolerability of treatment and the apparent dose independence of site pain. "
03/15/2002 - "The most common side effect attributed to treprostinil was infusion site pain (85%) leading to premature discontinuation from the study in 8% of patients. "
09/01/2013 - "The majority of diaries documented brief periods of severe pain, but this had generally abated by day 7. Contrary to published guidelines, infusion site pain was independent of treprostinil dose in a rigorous analysis. "
12/24/2012 - "Pain at the infusion site has been a major drawback of subcutaneous treprostinil, hampering dose titration, and ultimately leading to increased discontinuation rates. "
11/01/2010 - "Dosing to achieve rapid onset of efficacy and proactively managing infusion site pain enhance the likelihood for a patient with PAH to maintain and derive benefit from SC treprostinil therapy."
06/01/2013 - "Treprostinil is associated with the incidence of Gram-negative bacterial bloodstream infections (BSI), a susceptibility that has been associated with a diluent used for treprostinil. "
06/01/2010 - "These results suggest that dilution of treprostinil with the alkaline solution SDF may reduce the risk of infection from inadvertent patient contamination compared with dilution of treprostinil in sterile saline."
04/01/2008 - "In September 2006, the Centers for Disease Control and Prevention was notified of cases of gram-negative bloodstream infection (BSI) occurring among outpatients who received an intravenous formulation of the prostanoid treprostinil. "
03/02/2007 - "In September 2006, CDC received a report from a PAH specialist of a suspected increase in the number of gram-negative bloodstream infections (BSIs) among PAH patients treated with IV treprostinil. "
09/01/2009 - "The closed-hub system and the maintenance of dry catheter hub connections significantly reduced the incidence of CR-BSI (particularly infections caused by gram-negative pathogens) in patients receiving intravenous treprostinil."
|5.||Wounds and Injuries (Trauma)
|2.||Idiopathic pulmonary hypertension
|4.||Renal Dialysis (Hemodialysis)