humanin

suppresses neuronal cell death induced by the Swedish mutant of amyloid precursor protein; suppresses neuronal cell death induced by three different types of FAD genes and amyloid beta; amino acid sequence in first source

Also Known As:

Networked: 208 relevant articles (28 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Matsuoka, Masaaki: 21 articles (07/2019 - 03/2004)
2.	Cohen, Pinchas: 19 articles (01/2022 - 08/2006)
3.	Niikura, Takako: 17 articles (10/2022 - 05/2002)
4.	Hashimoto, Yuichi: 17 articles (09/2017 - 05/2002)
5.	Aiso, Sadakazu: 13 articles (06/2012 - 05/2002)
6.	Nishimoto, Ikuo: 13 articles (06/2009 - 05/2002)
7.	Yen, Kelvin: 11 articles (01/2021 - 02/2013)
8.	Wan, Junxiang: 9 articles (01/2022 - 11/2011)
9.	Kim, Su-Jeong: 8 articles (01/2021 - 07/2016)
10.	Kita, Yoshiko: 8 articles (08/2008 - 05/2002)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2018 - "In conclusion, humanin exerted neuroprotection during induced cardiac I/R injury via improvement in brain mitochondrial function, and the reduction of Alzheimer's disease pathology and apoptosis." 07/18/2017 - "The persistence, or loss, of a functional Humanin gene may be an important factor in laboratory animals, especially if they are being used as animal models in studies of Alzheimer's disease (AD). " 01/01/2022 - "Humanin and Alzheimer's disease: The beginning of a new field." 06/26/2020 - "Humanin was discovered in the surviving brain cells of patients with Alzheimer's disease. " 01/01/2015 - "Humanin inhibits neuronal cell death that is caused by a familial Alzheimer's disease (AD)-linked gene via binding to the heterotrimeric Humanin receptor (htHNR). "
2.	Cognitive Dysfunction 01/01/2019 - "Although humanin has also proven to be beneficial in ameliorating cognitive impairment induced by different insults, its putative actions on structural synaptic plasticity have not been fully addressed. " 01/01/2018 - "Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans." 08/11/2022 - "Treatment of a murine mTBI model with humanin reversed cognitive impairment caused by mTBI through the restoration of metabolic pathways within astrocytes. " 01/01/2020 - "The association between disease and human genetic variation in MDPs is underexplored, although two polymorphisms in humanin and MOTS-c associate with cognitive decline and diabetes, respectively, suggesting a precise role for MDPs in disease-modification. " 01/01/2019 - "Reduced astroglial-derived humanin may represent an underlying mechanism for synaptic dysfunction and cognitive decline after menopause."
3.	Inflammation (Inflammations) 04/06/2023 - "Humanin, on the other hand, seems to contrast the development of such conditions, and it is also known to play a role in these diseases by promoting the death of damaged or malfunctioning cells and contributing to the inflammation often associated with them. " 01/01/2022 - "Humanin has been shown to modulate multiple biological processes including autophagy, ER stress, cellular metabolism, oxidative stress, and inflammation. " 01/01/2023 - "Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis." 01/01/2022 - "Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD)." 01/01/2022 - "In conclusion, we present novel findings that: A) show reduced Humanin protein levels in AMD plasma vs. normal plasma; B) suggest the role of inflammatory markers in AMD pathogenesis, and C) highlight the positive effects of Humanin G in reducing inflammation in AMD."
4.	Hypoxia (Hypoxemia) 01/01/2022 - "In this review, we discuss the conservation of humanin-homologues across champion hibernators, anoxia and freeze-tolerant vertebrates and postulate on the putative roles of humanin in non-model species. " 01/01/2021 - "In this study we have used de novo and homology-based protein modelling to elucidate the putative structure of humanin in red-eared sliders as well as an ELISA and western immunoblotting to confirm the protein abundance in the turtle brain and six peripheral tissues during control, 5 h, and 20 h anoxia (n = 4/group). " 01/01/2021 - "Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles." 01/01/2014 - "Humanin attenuated the change of voltage-dependent potassium currents in hippocampal neurons induced by anoxia." 10/08/2010 - "Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury."
5.	Mitochondrial Diseases (Mitochondrial Disease) 12/01/2016 - "Humanin analogue pretreatment exerted cardioprotective effects against I/R injury through the attenuation of cardiac mitochondrial dysfunction." 01/01/2016 - "Only the humanin treatment before ischaemia attenuated brain mitochondrial dysfunction, but it did not prevent BBB breakdown or brain oxidative stress. " 01/01/2016 - "Only the humanin treatment before ischaemia attenuated brain mitochondrial dysfunction, but it did not prevent blood-brain barrier breakdown or brain oxidative stress. " 01/01/2018 - "Humanin analogue (HNG) given prior to cardiac ischemia has been shown to attenuate both heart and brain mitochondrial dysfunction caused by cardiac I/R injury. " 12/01/2016 - "Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Gly(14)-Humanin
3.	Amyloid beta-Peptides
4.	Colivelin
5.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
6.	Proteins (Proteins, Gene)
7.	Acids
8.	Glucose (Dextrose)
9.	Neuroprotective Agents
10.	Amino Acids

Related Therapies and Procedures

1.	Contraception (Birth Control)
2.	Injections
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)