|1.||Russo, Patrizia: 4 articles (04/2003 - 01/2002)|
|2.||Falugi, Carla: 3 articles (04/2003 - 07/2002)|
|3.||Trombino, Sonya: 3 articles (04/2003 - 07/2002)|
|4.||Malacarne, Davide: 2 articles (07/2002 - 01/2002)|
|5.||O'Connor, Patrick M: 2 articles (07/2002 - 01/2002)|
|6.||Crippa, A: 2 articles (09/2001 - 04/2001)|
|7.||Ottoboni, C: 2 articles (09/2001 - 04/2001)|
|8.||Russo, P: 2 articles (09/2001 - 04/2001)|
|9.||Margaritora, Stefano: 1 article (04/2003)|
|10.||Granone, Pierluigi: 1 article (04/2003)|
|1.||Colonic Neoplasms (Colon Cancer)
07/20/2002 - "RPR-115135, a farnesyltransferase inhibitor, increases 5-FU- cytotoxicity in ten human colon cancer cell lines: role of p53."
09/01/2001 - "To investigate the relationship between oncogene activation and induction of micronuclei by a new non-peptidic mimetic farnesyltransferase inhibitor, RPR-115135, two isogenic cell lines, human colon cancer line HCT-116, which harbors a K-ras mutation, and spontaneously immortalized human breast epithelial cell line MCF-10A, were utilized. "
04/01/2001 - "A new non peptidomimetic farnesyltransferase inhibitor, RPR-115135, was studied in an isogenic cell model system consisting of human colon cancer HCT-116 line. "
01/01/1999 - "Cellular effects of a new farnesyltransferase inhibitor, RPR-115135, in a human isogenic colon cancer cell line model system HCT-116."
07/20/2002 - "A new non peptidic farnesyltransferase inhibitor, RPR-115135, in combination with 5-FU was studied in 10 human colon cancer cell lines (HCT-116, RKO, DLD-1, Colo-320, LoVo, SW-620, HT-29, HCT-15, Colo-205 and KM-12) carrying several mutations but well characterized for p53 and Ras status. "
04/01/2003 - "As an example, RPR-115135 induced micronuclei (MN) increase in cancer cells displaying high chromosome instability (CIN) levels, whereas in normal cells it is devoid of activity. "
01/01/2003 - "A therapeutic strategy that relies on the use of c-myc antisense in combination with a farnesyltransferase inhibitor, RPR-115135 (C31H29NO4), was studied in human cancer cell lines carrying different mutations (Ras, p53, myc amplification). "
01/01/2003 - "c-myc down-regulation induces apoptosis in human cancer cell lines exposed to RPR-115135 (C31H29NO4), a non-peptidomimetic farnesyltransferase inhibitor."
|3.||Chromosomal Instability (Chromosome Stability)