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3- (3- (3- (4,5- dihydroimidazol- 2- ylamino)propyloxylisoxazol- 5- yl)carbonylamino)- 2- (phenylsulfonylamino)propionic acid

alpha(v)beta(3)-receptor antagonist

Also Known As:

XT199

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 3-(3-(3-(4,5-dihydroimidazol-2-ylamino)propyloxylisoxazol-5-yl)carbonylamino)-2-(phenylsulfonylamino)propionic acid: 2

Experts

1.	Bharali, Dhruba J: 1 article (01/2020)
2.	Celikler, Serap: 1 article (01/2020)
3.	Davis, Paul J: 1 article (01/2020)
4.	Debreli Coskun, Melis: 1 article (01/2020)
5.	Mousa, Shaker A: 1 article (01/2020)
6.	Sudha, Thangirala: 1 article (01/2020)
7.	Bishop, G G: 1 article (04/2001)
8.	Feldman, M J: 1 article (04/2001)
9.	Gimple, L W: 1 article (04/2001)
10.	Hesselbacher, S E: 1 article (04/2001)

Related Diseases

1.	Peripheral Nervous System Diseases (PNS Diseases) 01/01/2020 - "This study was undertaken to investigate whether αvβ3 integrin receptor antagonist compounds NDAT and XT199 can suppress the development of cisplatin resistance and cisplatin-induced peripheral neuropathy in an orthotopic pancreatic SUIT2-luc cancer cell mouse model. "
2.	Neoplasms (Cancer) 01/01/2020 - "Results clearly suggest that NDAT and XT199 treatment with cisplatin that inactivates NF-κB may contribute to increased antitumor and anti-inflammatory efficacy as well as alleviate cisplatin-mediated loss of motor function in this pancreatic tumor mouse model." 01/01/2020 - "The combination therapy of NDAT or XT199 with cisplatin elicited greater inhibition of tumor growth and increased tumor necrosis compared to cisplatin alone. " 01/01/2020 - "This study was undertaken to investigate whether αvβ3 integrin receptor antagonist compounds NDAT and XT199 can suppress the development of cisplatin resistance and cisplatin-induced peripheral neuropathy in an orthotopic pancreatic SUIT2-luc cancer cell mouse model. "
3.	Atherosclerosis 04/10/2001 - "After induction of focal atherosclerosis, rabbits underwent femoral BA and received XT199 (2.5 mg/kg IV bolus plus 2.5 mg. kg(-1). "
4.	Necrosis 01/01/2020 - "The combination therapy of NDAT or XT199 with cisplatin elicited greater inhibition of tumor growth and increased tumor necrosis compared to cisplatin alone. "

Related Drugs and Biologics

1.	Integrins
2.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Therapeutics