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ximelagatran (Exanta)

prodrug (via hydroxylation) of melagatran & a direct thrombin inhibitor; liver toxicity concerns so AZD0837 being developed to replace this
Also Known As:
Exanta; H 376 95; H 376-95; glycine, N-((1)1-cyclohexyl-2-((2)-((((4-(amino(hydroxyimino)methyl)phenyl)methyl)amino)carbonyl)-1-azetidinyl)2-oxoethyl)-ethyl ester; glycine, N-((1R)1-cyclohexyl-2-((2S)-((((4-(amino(hydroxyimino)methyl)phenyl)methyl)amino)carbonyl)-1-azetidinyl)2-oxoethyl)-ethyl ester; xi-melagatran
Networked: 233 relevant articles (40 outcomes, 121 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Eriksson, Ulf G: 16 articles (04/2012 - 02/2002)
2. Frison, Lars: 10 articles (11/2008 - 02/2002)
3. Wåhlander, Karin: 9 articles (04/2012 - 08/2002)
4. Halperin, Jonathan L: 9 articles (08/2009 - 09/2003)
5. Bylock, Anders: 8 articles (02/2008 - 02/2002)
6. Eriksson, Henry: 8 articles (04/2006 - 08/2002)
7. Eriksson, Bengt I: 7 articles (01/2006 - 02/2002)
8. Wolzt, Michael: 6 articles (04/2012 - 02/2003)
9. Lip, Gregory Y H: 6 articles (09/2010 - 12/2004)
10. Grind, Margaretha: 6 articles (06/2007 - 03/2003)

Related Diseases

1. Stroke (Strokes)
2. Atrial Fibrillation
3. Venous Thromboembolism
4. Hemorrhage
5. Venous Thrombosis (Deep-Vein Thrombosis)

Related Drugs and Biologics

1. Thrombin
2. Warfarin (Coumadin)
3. Enoxaparin (Lovenox)
4. Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)
5. melagatran
6. Anticoagulants
7. Aspirin (Acetylsalicylic Acid)
8. Vitamin K
9. idraparinux
10. Factor Xa (Coagulation Factor Xa)

Related Therapies and Procedures

1. Knee Replacement Arthroplasty (Total Knee Replacement)
2. Arthroplasty
3. Hip Replacement Arthroplasty (Total Hip Replacement)
4. Oral Administration
5. Orthopedic Procedures