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cassine

RN given for (2S-(2alpha,5alpha,6alpha))-isomer

Also Known As:

12-(5-hydroxy-6-methylpiperidin-2-yl)dodecan-2-one

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bolzani, Vanderlan S: 1 article (02/2012)
2.	Calixto, João B: 1 article (02/2012)
3.	Manjavachi, Marianne Neves: 1 article (02/2012)
4.	Paszcuk, Ana Flávia: 1 article (02/2012)
5.	Pivatto, Marcos: 1 article (02/2012)
6.	Viegas, Claudio: 1 article (02/2012)
7.	da Silva, Kathryn A B S: 1 article (02/2012)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 02/01/2012 - "Altogether, the present data demonstrate that (-)-cassine has systemic, spinal and supraspinal anti-nociceptive properties when assessed in inflammatory and neuropathic pain models. " 02/01/2012 - "Plant derived alkaloid (-)-cassine induces anti-inflammatory and anti-hyperalgesics effects in both acute and chronic inflammatory and neuropathic pain models."
2.	Hyperalgesia 02/01/2012 - "Moreover, (-)-cassine (1-10 μg/site) prevented mechanical hyperalgesia induced by carrageenan when given through the intraplantar (i.pl.), spinal and intracerebroventricular routes. " 02/01/2012 - "Additionally, oral treatment with (-)-cassine (3-60 mg/kg) prevented the mechanical hyperalgesia elicited by intraplantar injection of prostaglandin E(2), complete Freund's adjuvant, interleukin-1β, interleukin-6 and keratinocyte-derived chemokine. "
3.	Catalepsy 02/01/2012 - "It is important to highlight that oral treatment with (-)-cassine did not produce any effects related to temperature, locomotor activity or catalepsy. "

Related Drugs and Biologics

1.	Chemokines
2.	Interleukin-6 (Interleukin 6)
3.	Prostaglandins
4.	Freund's Adjuvant
5.	Carrageenan
6.	Alkaloids