eIF-5A2

eIF-5A2 shares 82% identity of amino acid sequence with eIF-5A including the minimum domain needed for eIF-5A maturation by hypusine modification at lysine-50 residue; amino acid sequence in first source

Also Known As:

Networked: 10 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Guan, Xin-Yuan: 6 articles (05/2011 - 06/2004)
2.	Xie, Dan: 5 articles (05/2009 - 06/2004)
3.	Kung, Hsiang-Fu: 4 articles (05/2009 - 01/2008)
4.	Chen, Wei: 3 articles (11/2015 - 02/2009)
5.	Hua, Wen-Feng: 3 articles (05/2009 - 02/2009)
6.	Luo, Jun-Hang: 3 articles (05/2009 - 02/2009)
7.	Zeng, Yi-Xin: 3 articles (05/2009 - 02/2009)
8.	Ma, Ning-Fang: 2 articles (01/2008 - 06/2004)
9.	Du, Feiya: 1 article (11/2015)
10.	Fu, Peifen: 1 article (11/2015)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 11/01/2015 - "The eIF-5A2 expression levels varied among breast cancer cells. " 11/01/2015 - "However, eIF-5A2 overexpression in breast cancer and its effect on chemotherapy are unknown. " 11/01/2015 - "Silencing of eIF-5A2 significantly improved doxorubicin toxicity in all three breast cancer cell lines. " 11/01/2015 - "This study shows that eIF-5A2 plays an important role in doxorubicin chemoresistance in breast cancer cells." 11/01/2015 - "We measured eIF-5A2 expression and doxorubicin sensitivity in different human breast cancer cell lines (Bcap-1937, HCC1937, and MCF-7). "
2.	Neoplasms (Cancer) 05/26/2011 - "Functional study has demonstrated the oncogenic role of eIF-5A2 in the initiation and progression of human cancers. " 05/26/2011 - "Instead of resulting in spontaneous tumor formation, overexpression of eIF-5A2 accelerated the aging process in adult transgenic mice. " 05/01/2009 - "Importantly, multivariate Cox regression analysis revealed that EIF-5A2 expression provided a significant independent prognostic parameter either in tumor recurrence (P = 0.002) or in tumor progression (P = 0.007). " 01/01/2008 - "In addition, significant positive associations were found between EIF-5A2 overexpression and the tumors' later pN and pM stages, as well as increased tumor cell proliferation (P < .05). " 05/01/2009 - "Overexpression of EIF-5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladder."
3.	Carcinogenesis 02/01/2009 - "Our previous study has suggested an oncogenic role of eIF-5A2 in ovarian tumorigenesis. " 02/01/2009 - "Our previous study has suggested an oncogenic role of eIF-5A2 in ovarian tumorigenesis. " 01/01/2008 - "Our previous study has suggested an oncogenic role of eIF-5A2 in ovarian tumorigenesis. "
4.	Carcinoma (Carcinomatosis) 05/01/2009 - "The authors investigated the status of abnormalities of eIF-5A2 gene in superficial (pTa/pT1) urothelial carcinoma of the bladder (UC), as well as its correlation with clinicopathologic variables and patient outcome. " 02/01/2009 - "In univariate survival analysis of the ovarian carcinoma cohorts, a significant association of overexpression of EIF-5A2 with shortened patient survival (mean 39.0 months vs 69.5 months, p<0.001) was demonstrated. " 02/01/2009 - "Amplification of eIF-5A2 was detected in 16% of informative ovarian carcinomas. " 02/01/2009 - "The amplification status of eIF-5A2 in each ovarian carcinoma was assessed by fluorescence in situ hybridization. " 02/01/2009 - "Abnormalities of eIF-5A2 and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. "
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2008 - "These findings suggest that overexpression of EIF-5A2 in colorectal carcinomas may be important in the acquisition of a metastatic phenotype and plays an important role in colorectal carcinoma development and progression." 01/01/2008 - "In primary colorectal carcinomas, the frequency of EIF-5A2 overexpression was significantly higher in colorectal carcinomas with lymphovascular invasion (61.2%) than that in colorectal carcinomas without lymphovascular invasion (36.6%, P < .05). " 01/01/2008 - "Amplification of eIF-5A2 was detected in 15.8% (16/101) of informative colorectal carcinomas, and most of them showed overexpression of EIF-5A2. " 01/01/2008 - "Abnormalities of eIF-5A2, however, in colorectal carcinoma are unclear. " 01/01/2008 - "Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma."

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	Protein Isoforms (Isoforms)
3.	Antisense DNA
4.	Proteins (Proteins, Gene)
5.	Peptide Initiation Factors (Initiation Factor)
6.	Indicators and Reagents (Reagents)
7.	Enzymes
8.	Agar
9.	Eukaryotic Translation Initiation Factor 5A
10.	hypusine

Related Therapies and Procedures

1.	Cystectomy
2.	Drug Therapy (Chemotherapy)