|1.||Bradshaw, Tracey D: 5 articles (10/2013 - 02/2002)|
|2.||Sausville, Edward A: 5 articles (07/2006 - 02/2002)|
|3.||Stevens, Malcolm F G: 4 articles (10/2011 - 02/2002)|
|4.||Monks, Anne: 3 articles (03/2006 - 03/2003)|
|5.||Brantley, Eileen: 2 articles (05/2015 - 07/2006)|
|6.||Stinson, Sherman F: 2 articles (07/2006 - 02/2002)|
|7.||Connelly, John: 2 articles (03/2006 - 03/2003)|
|8.||Bibby, Michael C: 2 articles (12/2004 - 02/2002)|
|9.||Amis, Louisa H: 1 article (05/2015)|
|10.||Zylstra, Dain: 1 article (05/2015)|
|1.||Breast Neoplasms (Breast Cancer)
03/01/2003 - "Genotoxic profiling of MCF-7 breast cancer cell line elucidates gene expression modifications underlying toxicity of the anticancer drug 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole."
02/01/2002 - "Plasma concentrations of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (2) regenerated from the lysylamide prodrug (2b), sufficient to elicit cytocidal activity against ZR-75-1 and T47D human mammary carcinoma cell lines persist > 6 h. "
05/18/2015 - "Investigational agent 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203) induces aryl hydrocarbon receptor (AhR)-mediated DNA damage in certain breast cancer cells. "
10/01/2011 - "Although depletion of CYP2S1 sensitized both breast cancer and CRC cells toward 5F-203 and GW-610, CYP2W1 knockdown caused marked resistance to GW-610 in CRC cells. "
03/01/2003 - "To characterize more completely the pathways involved in 5F-203 toxicity, cDNA microarrays were used to determine gene expression changes in MCF-7, a 5F-203-sensitive breast cancer cell line, after treatment with 1 microM 5F-203. "
|2.||Colorectal Neoplasms (Colorectal Cancer)
05/15/2009 - "2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203) and related compounds are a series of anti-cancer candidate pharmaceuticals, that have been shown to activate the AhR. "
03/01/2006 - "Further analyses of these expression data in 60 cell lines suggested that a smaller subset of genes could be used to classify tumor cell sensitivity to 5F-203. "
03/01/2003 - "In contrast to the MCF-7 data, MDA-MB-435, a cancer cell line resistant to 5F-203, showed no change in expression of any of these genes or the p53 protein under the same conditions of 5F-203 treatment. "
12/01/2003 - "Fine needle aspirates were obtained from a variety of human tumor xenografts, and treated ex vivo with 1 micro M 5F-203 for 24 h. "
12/01/2004 - "Its mechanism of action involves induction of CYP1A1-catalyzed biotransformation of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203) to generate electrophilic species, which covalently bind to DNA, exacting lethal damage to sensitive tumor cells, in vitro and in vivo. "
|4.||Ovarian Neoplasms (Ovarian Cancer)
|1.||2- (3,4- dimethoxyphenyl)- 5- fluorobenzothiazole
|2.||Cytochrome P-450 CYP1A1 (CYP1A1)
|3.||Biological Markers (Surrogate Marker)
|4.||DNA (Deoxyribonucleic Acid)
|5.||Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
|6.||Complementary DNA (cDNA)
|7.||Messenger RNA (mRNA)
|8.||Cytochrome P-450 Enzyme System (Cytochrome P450)
|1.||Heterologous Transplantation (Xenotransplantation)