|1.||Sundberg, John P: 9 articles (12/2015 - 03/2010)|
|2.||Iwai, Kazuhiro: 4 articles (07/2015 - 03/2011)|
|3.||Hogenesch, Harm: 4 articles (01/2014 - 03/2010)|
|4.||Liang, Yanhua: 4 articles (09/2011 - 01/2011)|
|5.||Dikic, Ivan: 3 articles (01/2014 - 03/2011)|
|6.||Potter, Christopher S: 3 articles (01/2014 - 11/2011)|
|7.||Wang, Zhe: 3 articles (01/2014 - 01/2012)|
|8.||Kennedy, Victoria E: 2 articles (12/2015 - 01/2014)|
|9.||Silva, Kathleen A: 2 articles (12/2015 - 01/2014)|
|10.||Cao, Yi: 2 articles (02/2015 - 10/2014)|
01/01/2014 - "These studies indicate that cutaneous inflammation in SHARPIN-deficient mice is autoinflammatory in nature developing independently of B and T lymphocytes, while the systemic inflammation seen in CPDM has a strong lymphocyte-dependent component. "
10/01/2012 - "Recent studies identified SHARPIN as an inhibitor of β1-integrin activation and signalling, and this may be another mechanism by which SHARPIN regulates inflammation. "
07/01/2015 - "Loss of function of SHARPIN in mice triggers chronic inflammation in multiple organs including the skin, as well as immunodeficiency. "
06/15/2014 - "After validating that the Ripk1(K45A) mice were specifically protected against necroptotic stimuli in vitro and in vivo, we crossed them with SHARPIN-deficient cpdm mice, which develop severe skin and multiorgan inflammation that has been hypothesized to be mediated by TNF-dependent apoptosis and/or necroptosis. "
01/01/2014 - "TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice."
09/01/2015 - "The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice."
01/01/2014 - "TSLP and IL33 were both increased in the skin of Sharpin(-/-) mice and this was maintained in Sharpin(-/-) , Il4ra(-/-) mice suggesting a role for TSLP and IL33 in the eosinophilic dermatitis in SHARPIN-deficient mice. "
03/31/2011 - "Mutation of the Sharpin gene (Sharpin(cpdm/cpdm)) causes chronic proliferative dermatitis (cpdm) characterized by inflammatory skin lesions and defective lymphoid organogenesis. "
01/01/2011 - "Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice."
03/01/2010 - "These data indicate that eosinophils are not essential for the development of dermatitis in Sharpin(cpdm) mice and suggest that eosinophils have both pro-inflammatory and anti-inflammatory roles in the skin of these mice."
10/15/2014 - "Nuclear factor κB (NFκB) signaling is strongly associated with tumor progression, and studies have shown that SHANK-associated RH domain interacting protein (SHARPIN) is crucial for NFκB pathway activation. "
11/01/2011 - "SHARPIN inhibited β1-integrin functions in human cancer cells and primary leukocytes. "
07/01/2010 - "Taken together, the results suggest that Sharpin is not an inert scaffold protein, but may play tumor-associated roles during cancer biogenesis."
07/01/2010 - "In addition, Chinese ovary hamster cells over-expressing Sharpin exhibited enhanced cancer-specific phenotypes in multiple in vitro tumor assays. "
07/01/2010 - "Among those differentially regulated genes, we identified Sharpin (Shank-associated RH domain-interacting protein) as a commonly up-regulated gene in multiple human cancer types. "
02/01/2015 - "SHARPIN emerges higher expression in prostate cancerous tissues than in benign prostate hyperplasia by means of immunohistochemistry in our previous study. "
12/01/2015 - "SHARPIN-deficient cpdm mice develop a chronic proliferative dermatitis and an esophagitis characterized by epithelial hyperplasia and the accumulation of eosinophils in the serosa, submucosa, lamina propria and epithelium of the esophagus. "
01/01/2014 - "Mice lacking Sharpin develop a phenotype known as chronic proliferative dermatitis (CPDM), typified by progressive epidermal hyperplasia, apoptosis of keratinocytes, cutaneous and systemic eosinophilic inflammation, and hypoplasia of secondary lymphoid organs. "
|5.||Prostatic Neoplasms (Prostate Cancer)
02/01/2015 - "SHARPIN overexpression induces tumorigenesis in human prostate cancer LNCaP, DU145 and PC-3 cells via NF-κB/ERK/Akt signaling pathway."
10/15/2014 - "However, the expression and functions of SHARPIN in prostate cancer (PCa) have not yet been defined. "
10/15/2014 - "Activation of nuclear factor κB pathway and downstream targets survivin and livin by SHARPIN contributes to the progression and metastasis of prostate cancer."
02/01/2015 - "Collectively, our study unraveled the ability of SHARPIN overexpression to induce tumorigenesis of prostate cancer cells through the NF-kB/ERK/Akt pathway and transformation of apoptosis-associated proteins. "
|3.||NF-kappa B (NF-kB)
|4.||Proteins (Proteins, Gene)
|6.||Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
|7.||TNF Receptor-Associated Factor 6 (TRAF6)
|8.||Type I Tumor Necrosis Factor Receptors
|9.||Proteasome Endopeptidase Complex (Proteasome)