T0901317

an LXRalpha and LXRbeta agonist

Also Known As:

N-(2,2,2-Trifluoroethyl)-N-(4-(2,2,2-trifluoro-1- hydroxy-1-trifluoromethylethyl)phenyl)benzenesulfonamide; N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide; N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide; T 0901317; T 1371; T-0901317; T-1371; T1371 cpd

Networked: 124 relevant articles (7 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Yuanli: 7 articles (01/2021 - 04/2014)
2.	Duan, Yajun: 7 articles (01/2021 - 04/2014)
3.	Han, Jihong: 7 articles (01/2021 - 04/2014)
4.	Hiipakka, Richard A: 7 articles (04/2011 - 11/2004)
5.	Liao, Shutsung: 7 articles (04/2011 - 11/2004)
6.	Li, Xiaoju: 6 articles (01/2021 - 04/2014)
7.	Yang, Xiaoxiao: 6 articles (01/2021 - 04/2015)
8.	Kokontis, John M: 5 articles (04/2011 - 11/2004)
9.	Ma, Chuanrui: 4 articles (01/2021 - 12/2018)
10.	Ma, Xingzhe: 4 articles (12/2018 - 04/2014)

Related Diseases

1.	Insulin Resistance 01/01/2014 - "T0901317 treatment induced significant insulin resistance in C57BL/6 mice. " 01/10/2003 - "In insulin-resistant Zucker (fa/fa) rats, T0901317 significantly improved insulin sensitivity. " 01/01/2013 - "The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance." 01/01/2013 - "Twice weekly intraperitoneal injections of T0901317 at 50 mg/kg in animals on the same diet completely blocked obesity development, obesity-associated insulin resistance, and glucose intolerance. " 01/01/2013 - "Treatment of high fat diet-induced obese mice with T0901317, an LXR activator, or fenofibrate, the PPARα agonist, or in combination alleviated insulin resistance and improved glucose tolerance. "
2.	Inflammation (Inflammations) 07/01/2015 - "This study investigates whether LXR agonist T0901317 may modulate viral replication and cardiac inflammation during VM. " 12/01/2021 - "The LXRs agonist T0901317 may reduce the inflammation of alveolar epithelial cells induced by PHMG by inhibiting the NFκB signaling pathway." 12/01/2021 - "This article explores the role of LXRs agonist T0901317 in the inflammation of alveolar epithelial cells induced by PHMG. " 05/01/2009 - "Pre-treatment with T0901317 before LPS stimulation can suppress the expressions of IRF3 and GRIP1 to inhibit the inflammation and hence Kupffer cell activation." 02/22/2010 - "Administration of T0901317, 30 min after the challenge with carrageenan, caused a significant reduction in a dose dependent manner of all the parameters of inflammation measured. "
3.	HIV Infections (HIV Infection) 09/01/2015 - "Pre-exposure of peripheral blood leukocytes to T0901317 provided only a short-term protection against HIV infection. " 09/01/2015 - "Pre-exposure of monocyte-derived macrophages to T0901317 reduced susceptibility of these cells to HIV infection in vitro. " 09/01/2015 - "In this study, we extended these observations by analyzing the effect of the LXR agonist T0901317 [N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide] on the ongoing HIV infection and investigating the possibility of using LXR agonist for pre-exposure prophylaxis of HIV infection in a humanized mouse model. "
4.	Cardiomegaly (Heart Hypertrophy) 01/01/2017 - "PAH rats demonstrated obvious cardiac hypertrophy and remodeling in the right ventricle, but significant improvement of cardiac hypertrophy and remodeling was observed in PAH rats treated with T0901317. " 01/01/2017 - "To further explore the protective effect of LXR in PAH-induced cardiac hypertrophy and remodeling, a PAH model was developed, and T0901317, an agonist of LXR, was used to examine the effect of LXR activation. " 10/01/2010 - "Activation of liver X receptors with T0901317 attenuates cardiac hypertrophy in vivo." 02/01/2012 - "T0901317, an agonist of LXRs, could inhibit ET-1 induced cardiac hypertrophy in vitro, and LXR ligand-mediated inhibition on ANP mRNA expression by T0901317 is receptor dependent."
5.	Ischemia 10/01/2023 - "T0901317, a liver X receptor agonist, ameliorates perinatal white matter injury induced by ischemia and hypoxia in neonatal rats." 10/01/2023 - "Herein, we investigated the role of LXRs in a neonatal rat model of white matter loss after hypoxia-ischemia (HI) injury through intraperitoneal injection of the LXR agonist T0901317 (T09) 1 day before and 15 min postinjury. "

Related Drugs and Biologics

1.	Ligands
2.	Insulin (Novolin)
3.	Carrageenan
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)
6.	Glucose (Dextrose)
7.	Fenofibrate (CiL)
8.	Liver X Receptors
9.	Cholesterol
10.	GW 3965

Related Therapies and Procedures

1.	Oral Administration
2.	Intraperitoneal Injections
3.	Resuscitation
4.	Punctures
5.	Ligation