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LG 268

an LXR ligand; no further iinformation available 4/2001

Also Known As:

LG-268; LG268

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- LG 268: 10

Experts

1.	Sporn, Michael B: 5 articles (01/2019 - 03/2007)
2.	Liby, Karen T: 2 articles (01/2019 - 11/2010)
3.	Risingsong, Renee: 2 articles (11/2010 - 05/2008)
4.	Royce, Darlene B: 2 articles (11/2010 - 05/2008)
5.	Williams, Charlotte R: 2 articles (11/2010 - 05/2008)
6.	Brinckerhoff, Constance E: 2 articles (01/2008 - 03/2007)
7.	Burrage, Peter S: 2 articles (01/2008 - 03/2007)
8.	Heyman, Richard A: 2 articles (02/2006 - 02/2004)
9.	Leibowitz, Mark D: 2 articles (02/2006 - 02/2004)
10.	Ogilvie, Kathleen M: 2 articles (02/2006 - 02/2004)

Related Diseases

1.	Chondrosarcoma 03/01/2007 - "SW-1353 human chondrosarcoma cells were used to study the effects of LG268 on interleukin-1beta (IL-1beta)-stimulated MMP production and collagen degradation. " 01/01/2008 - "We recently described the ability of retinoid X receptor (RXR) ligand LG100268 (LG268) to inhibit interleukin-1-beta (IL-1-beta)-driven matrix metalloproteinase-1 (MMP-1) and MMP-13 gene expression in SW-1353 chondrosarcoma cells. "
2.	Neoplasms (Cancer) 05/01/2008 - "The total tumor burden was 85% to 87% lower in mice fed LG268 and CDDO-MA than in controls, and the percentage of high-grade tumors decreased from 59% in the controls to 25% or 30% with CDDO-MA and LG268. " 01/01/2019 - "In the MMTV-PyMT murine model of triple negative breast cancer, LG268 treatment of established tumors prolonged survival, and in combination with anti-PD-L1 antibodies, significantly (p = 0.05) increased the infiltration of cytotoxic CD8 T cells and apoptosis. " 01/01/2019 - "Here, we report that treatment with LG 268, but not bexarotene, decreased infiltration of myeloid-derived suppressor cells and CD206-expressing macrophages, increased the expression of PD-L1 by 50%, and increased the ratio of CD8/CD4, CD25 T cells, which correlates with increased cytotoxic activity of CD8 T cells in tumors of MMTV-Neu mice (a model of HER2-positive breast cancer). " 05/01/2008 - "The rexinoid LG100268 (LG268), a selective ligand for the retinoid X receptor, and the methyl amide of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) both significantly reduced the number, size, and severity of the histopathology of lung tumors in female A/J mice when fed in diet for 14 to 20 weeks. "
3.	Inflammation (Inflammations) 01/01/2012 - "Systemic treatments with LG268 decreased the expression of genes involved in skin homeostasis, RA synthesis and skin RA concentrations, while it increased various markers for skin inflammation and RA degradation, which corresponds to decreased skin RARE signaling. " 08/01/2013 - "Two RXRα ligands, 9-cis retinoic acid (9cRA) and LG268, induced SUMOylation of RXRα, whereas both inflammation- and ligand-induced SUMOylation of RXRα require the K108 residue. "
4.	Triple Negative Breast Neoplasms 01/01/2019 - "Collectively, these data suggest that the use of LG268, a RXR agonist, can improve response to immune checkpoint blockade in HER2+ or triple-negative breast cancer." 01/01/2019 - "In the MMTV-PyMT murine model of triple negative breast cancer, LG268 treatment of established tumors prolonged survival, and in combination with anti-PD-L1 antibodies, significantly (p = 0.05) increased the infiltration of cytotoxic CD8 T cells and apoptosis. "
5.	Hypertriglyceridemia 02/01/2001 - "LG268 has no effect on hepatic triglyceride production but suppresses post-heparin plasma lipoprotein lipase (LPL) activity suggesting that the hypertriglyceridemia results from diminished peripheral processing of plasma very low density lipoproteins particles. "

Related Drugs and Biologics

1.	Interleukin-1beta (Interleukin 1 beta)
2.	Matrix Metalloproteinases (MMPs)
3.	Collagen
4.	LG 100268
5.	Retinoid X Receptors (Retinoid X Receptor)
6.	Ligands
7.	Triterpenes
8.	Insulin (Novolin)
9.	PPAR gamma
10.	Matrix Metalloproteinase 1 (Interstitial Collagenase)