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5'-deoxyribose phosphate lyase

Also Known As:

dRP lyase

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Lyases: 637
    - Phosphorus-Oxygen Lyases
      - 5'-deoxyribose phosphate lyase: 6

Experts

1.	Sweasy, Joann B: 2 articles (09/2015 - 02/2008)
2.	Sobol, R W: 2 articles (01/2001 - 06/2000)
3.	Wilson, S H: 2 articles (01/2001 - 06/2000)
4.	Kidane, Dawit: 1 article (09/2015)
5.	Nemec, Antoni A: 1 article (09/2015)
6.	Rozacky, Jenna: 1 article (09/2015)
7.	Bennett, Geoffrey R: 1 article (01/2014)
8.	Bundschuh, Ralf: 1 article (01/2014)
9.	Fishel, Richard: 1 article (01/2014)
10.	Hanne, Jeungphill: 1 article (01/2014)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 09/15/2015 - "Previously, we demonstrated that the human gastric cancer-associated variant of Pol β (Leu22Pro (L22P)) lacks dRP lyase function in vitro. " 01/01/2022 - "Specifically, it has been established that this loss of dRP lyase function promotes inflammation associated gastric cancer. "
2.	Hypersensitivity (Allergy) 06/15/2000 - "Here we show that only the dRP lyase activity of beta-pol is required to reverse methylating agent hypersensitivity in beta-pol null cells. " 01/01/2001 - "Further, the N-terminal 8-kDa domain of beta-pol, which contains the dRP lyase activity in the wild-type enzyme, is sufficient to reverse the methylating agent hypersensitivity in beta-pol null cells. "
3.	Genomic Instability 01/01/2022 - "Here we show that a dRP lyase deficient variant of POLB (Leu22Pro, or L22P) increases mitotic dysfunction associated genomic instability, which eventually leads to a cytosolic DNA mediated inflammatory response. " 01/01/2022 - "Previously, we have shown that deoxyribo-5'-phosphate (dRP) lyase deficient DNA polymerase beta (POLB) causes replication associated genomic instability and sensitivity to both endogenous and exogenous DNA damaging agents. "
4.	HIV Infections (HIV Infection) 01/01/2014 - "A DNA synthesis defective mutant, but not a 5'dRP lyase mutant, rescued HIV infection efficiency to wild type levels; this suggested Polβ DNA synthesis activity is not necessary while 5'dRP lyase activity is required for efficient HIV infection. "
5.	Neoplasms (Cancer) 02/01/2008 - "We show that this cancer-associated variant has very little dRP lyase activity but retains its polymerase activity. " 02/01/2008 - "The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient."

Related Drugs and Biologics

1.	DNA Polymerase beta (DNA Polymerase IV)
2.	DNA (Deoxyribonucleic Acid)
3.	A-Form DNA (A-DNA)
4.	Enzymes