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BIM 46228

farnesyltransferase inhibitor; structure in first source

Also Known As:

BIM-46228

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - BIM 46228: 1
Organic Chemicals: 133
- Nitriles: 227
  - BIM 46228: 1

Experts

1.	Ader, I: 1 article (03/2001)
2.	Brezak, M C: 1 article (03/2001)
3.	Favre, G: 1 article (03/2001)
4.	Gordon, T: 1 article (03/2001)
5.	Kasprzyk, P: 1 article (03/2001)
6.	Lonchampt, M O: 1 article (03/2001)
7.	Morgan, B: 1 article (03/2001)
8.	Pradines, A: 1 article (03/2001)
9.	Prevost, G P: 1 article (03/2001)
10.	Toulas, C: 1 article (03/2001)

Related Diseases

1.

Neoplasms (Cancer)

03/01/2001 - "Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of human farnesyltransferase, BIM-46228."
03/01/2001 - "Here, we report a novel FTase inhibitor, BIM-46228, which showed (i) specific inhibition of purified human FTase enzyme, (ii) inhibition of proliferation in vitro in a large spectrum of human tumor cell lines, (iii) inhibition of growth of human tumor xenografts in athymic nude mice treated by per os administration and (iv) the benefits of in vitro combination of its activity with chemotherapy or radiotherapy."

Related Drugs and Biologics

1.	Farnesyltranstransferase (Farnesyltransferase)
2.	p21(ras) farnesyl-protein transferase (protein farnesyltransferase)

Related Therapies and Procedures

1.	Radiotherapy
2.	Drug Therapy (Chemotherapy)