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TAK 456

structure in first source

Also Known As:

1-(2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-3-(4-(1H-1-tetrazolyl)phenyl)-2-imidazolidinone; TAK-456

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - TAK 456: 1
    - Tetrazoles: 14
      - TAK 456: 1

Experts

1.	Asai, Kentaro: 1 article (05/2002)
2.	Hayashi, Ryogo: 1 article (05/2002)
3.	Iizawa, Yuji: 1 article (05/2002)
4.	Itoh, Katsumi: 1 article (05/2002)
5.	Kitamoto, Naomi: 1 article (05/2002)
6.	Kitazaki, Tomoyuki: 1 article (05/2002)
7.	Okonogi, Kenji: 1 article (05/2002)
8.	Tsuchimori, Noboru: 1 article (05/2002)

Related Diseases

1.	Infections 05/01/2002 - "TAK-456 was effective against infections with two strains of fluconazole-resistant C. " 05/01/2002 - "In normal mice, TAK-456 and fluconazole were effective against infection caused by fluconazole-susceptible C. " 05/01/2002 - "albicans at a dose of 10 mg/kg. TAK-456 also expressed activities similar to or higher than those of itraconazole against the infections caused by two strains of A. " 05/01/2002 - "Therapeutic activities of TAK-456 and reference triazoles against systemic lethal infections caused by C. " 05/01/2002 - "albicans at a dose of 1 mg/kg. In transiently neutropenic mice, therapeutic activity of TAK-456 at 1 mg/kg of body weight against infection with the same strain was stronger than those at 1 mg/kg of fluconazole. "
2.	Candidiasis (Moniliasis) 05/01/2002 - "fumigatus in neutropenic mice at a dose of 10 mg/kg. These results suggest that TAK-456 is a promising candidate for development for the treatment of candidiasis and aspergillosis in humans."
3.	Body Weight (Weight, Body) 05/01/2002 - "albicans at a dose of 1 mg/kg. In transiently neutropenic mice, therapeutic activity of TAK-456 at 1 mg/kg of body weight against infection with the same strain was stronger than those at 1 mg/kg of fluconazole. "
4.	Aspergillosis 05/01/2002 - "fumigatus in neutropenic mice at a dose of 10 mg/kg. These results suggest that TAK-456 is a promising candidate for development for the treatment of candidiasis and aspergillosis in humans."

Related Drugs and Biologics

1.	Fluconazole (Zonal)
2.	Itraconazole (Sporanox)
3.	Triazoles