|1.||Honma, Yoshio: 12 articles (04/2015 - 06/2002)|
|2.||Kato, Nobuo: 8 articles (02/2015 - 01/2005)|
|3.||Sassa, Takeshi: 8 articles (09/2013 - 07/2003)|
|4.||Kasukabe, Takashi: 7 articles (08/2015 - 01/2005)|
|5.||Okabe-Kado, Junko: 4 articles (02/2015 - 01/2005)|
|6.||Ishii, Yuki: 3 articles (04/2006 - 07/2003)|
|7.||Kumakura, Shunichi: 2 articles (08/2015 - 02/2015)|
|8.||Ottmann, Christian: 2 articles (09/2013 - 03/2009)|
|9.||Inoue, Takatsugu: 2 articles (09/2013 - 03/2009)|
|10.||Akimoto, Miho: 2 articles (07/2008 - 11/2007)|
|1.||Myeloid Leukemia (Leukemia, Myelocytic)
03/02/2011 - "However, only cotylenin A induces the differentiation of human myeloid leukemia cells. "
04/01/2006 - "Cotylenin A, which has been isolated as a plant growth regulator, potently induces the differentiation of human myeloid leukemia cells. "
06/01/2002 - "Cotylenin A--a plant growth regulator as a differentiation-inducing agent against myeloid leukemia."
09/29/1997 - "Here we report that at the concentrations above 12.5 microg/ml (20 microM) cotylenin A induced the functional and morphological differentiation in murine (M1) and human myeloid leukemia (HL-60) cells. "
09/29/1997 - "Cotylenin A, a plant-growth regulator, induces the differentiation in murine and human myeloid leukemia cells."
02/01/2013 - "In this study, we found that cotylenin A could suppress rapamycin-induced phosphorylation of Akt (Ser473) in MCF-7 cells and lung carcinoma A549 cells and that cotylenin A also enhanced the rapamycin-induced growth inhibition of MCF-7 and A549 cells. "
12/01/2005 - "Antitumor effect of cotylenin A plus interferon-alpha: possible therapeutic agents against ovary carcinoma."
01/01/2005 - "Effects of combined treatment with rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts."
11/01/2007 - "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor DR5 were early genes induced by the combination of cotylenin A and IFNalpha in carcinoma cells. "
07/01/2003 - "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor DR5 were the early genes induced by the combination of cotylenin A and IFN alpha in lung carcinoma cells. "
|3.||Breast Neoplasms (Breast Cancer)
02/01/2015 - "These results suggest that cotylenin A is an attractive enhancer for the ATO-induced anticancer activities in human breast cancer."
02/01/2015 - "In the present study, we found that cotylenin A, a plant growth regulator and a potent inducer of differentiation in myeloid leukemia cells, significantly potentiated both ATO-induced inhibition of cell growth in a liquid culture, and ATO-induced inhibition of anchorage-independent growth in a semi-solid culture in human breast cancer MCF-7 and MDA-MB-231 cells. "
02/01/2015 - "Cotylenin A and arsenic trioxide cooperatively suppress cell proliferation and cell invasion activity in human breast cancer cells."
08/01/2008 - "Recently, we found that cotylenin A and rapamycin effectively inhibited the proliferation of several human breast cancer cell lines including MCF-7. "
02/01/2013 - "Cotylenin A, a plant growth regulator, and rapa-mycin, an inhibitor of the mammalian target of rapamycin, are potent inducers of differentiation in myeloid leukemia cells and also synergistically inhibit the proliferation of several human breast cancer cell lines including MCF-7 in vitro and in vivo. "
04/01/2015 - "Cotylenin A has been shown to inhibit the growth of various cancer cells. "
09/20/2013 - "Stabilization of physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for RAS mutant cancers."
03/06/2009 - "Cotylenin A, a fungal metabolite originally described as a cytokinin-like bioactive substance against plants shows differentiation-inducing and anti-tumor activity in certain human cancers. "
11/01/2007 - "Among the differentiation inducers tested, the sensitivity of cancer cells to IFNalpha was most strongly affected by cotylenin A. "
12/01/2005 - "Recently, we found that cotylenin A and IFNalpha synergistically inhibited growth both in vitro and in vivo, and induced apoptosis in human cancer cells. "
11/01/2003 - "Cotylenin A may be useful for differentiation therapy of retinoid-resistant leukemia."
11/01/2003 - "In an in vivo analysis, cotylenin A induced the differentiation of leukemia cells in a retinoid-resistant leukemia model. "
11/01/2003 - "Treatment of human promyelocytic leukemia in the SCID mouse model with cotylenin A, an inducer of myelomonocytic differentiation of leukemia cells."
11/01/2007 - "Cotylenin A, which is a novel fusicoccane diterpene glycoside with a complex sugar moiety, affected the differentiation of leukemia cells that were freshly isolated from acute myelogenous leukemia patients in primary culture. "
07/01/2003 - "Cotylenin A, a novel inducer of the differentiation of leukemia cells, and IFN-alpha synergistically inhibited the growth of and induced apoptosis in several human non-small cell lung carcinoma cell lines. "
|3.||TNF-Related Apoptosis-Inducing Ligand Receptors
|4.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|5.||14-3-3 Proteins (14-3-3 Protein)
|6.||Vitamin K 2 (Vitamin K2)
|7.||Interferon-alpha (Interferon Alfa)
|8.||Transforming Growth Factor beta (TGF-beta)
|9.||Messenger RNA (mRNA)
|10.||lithocholic acid acetate
|1.||Heterologous Transplantation (Xenotransplantation)