telomerase RNA (bTR)

RNA component of telomerase

Also Known As:

bTR; TERC; TERC RNA; TERC RNA, human; TERC RNA, mouse; TERC RNA, rat; bovine telomerase RNA; hTR RNA; hterc; telomerase RNA component; telomerase RNA component, human; telomerase RNA component, mouse; telomerase RNA component, rat

Networked: 749 relevant articles (16 outcomes, 113 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Young, Neal S: 16 articles (01/2016 - 08/2003)
2.	Lansdorp, Peter M: 14 articles (11/2017 - 08/2003)
3.	Calado, Rodrigo T: 12 articles (06/2014 - 11/2002)
4.	Dokal, Inderjeet: 12 articles (03/2012 - 06/2002)
5.	Mason, Philip J: 12 articles (01/2009 - 06/2002)
6.	Bessler, Monica: 10 articles (01/2009 - 06/2003)
7.	Blasco, María A: 10 articles (11/2008 - 01/2002)
8.	Blackburn, Elizabeth H: 9 articles (09/2010 - 12/2002)
9.	Chanock, Stephen J: 8 articles (12/2016 - 08/2003)
10.	Nishiguchi, Shuhei: 8 articles (06/2016 - 03/2003)

Related Diseases

1.	Neoplasms (Cancer) 10/01/1998 - "Cytology was positive in 5 patients, whereas telomerase RNA was positive in 6. All malignancies were diagnosed by either cytology or telomerase RNA; however, both studies were positive in only 3. There were no false-positive results by either technique. " 01/01/2020 - "The sensitive imaging of telomerase RNA (TR) in living cells is crucial for improved guidance in cancer clinical diagnosis because its expression level is closely related to malignant diseases. " 01/01/2023 - "A study conducted by the FISH method revealed the amplification of the TERC gene, which indicates the malignant nature of this neoplasm. " 01/01/2021 - "The study focused on significant advances in practical 3DP-B SCF that can be utilized for tumor treatment as well as bone tissue regeneration (BTR). " 08/01/2005 - "In addition, to undertake a linkage study between the BTR database and that of the WA Cancer Registry (WACR) for the years 1980-1996 to determine if the BTR records could be regarded as population-based and valid for determining incidence rates in WA. "
2.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2019 - "The results supported that supplementation with BCAA-enriched LESs improved BTR, and long-term supplementation with BCAAs (>1 month) may be more beneficial than short-term supplementation (<1 month) in patients with liver cirrhosis. " 10/03/2017 - "Significantly longer event-free survival was found in liver cirrhosis patients with BTR ≥ 4 (n = 425) compared with those with BTR < 4 (n = 105), and the BTR was associated with liver cirrhosis events. " 01/01/2015 - "The new metabolism-related index, GA/HbA1c/BTR value, is shown to relate to the degree of liver fibrosis in HCV-positive patients. " 05/01/2013 - "A decreased BTR value was found to be associated with the progression of liver fibrosis and severity of varices." 01/01/1999 - "Competitive RT-PCR indicated that the relative amount of human telomerase RNA (hTR) was significantly higher in chronic hepatitis or liver cirrhosis compared with the normal liver (p < 0.005), and in HCC compared with the normal liver (p < 0.001) and with chronic hepatitis or liver cirrhosis (p < 0.0001). "
3.	Fibrosis (Cirrhosis) 05/01/2013 - "The mean values of the BTR decreased with the progression of the fibrosis (METAVIR score: F0-1: 6.40 ± 1.19; F2: 5.85 ± 1.33; F3: 5.24 ± 0.97, F4: 4.78 ± 1.14). " 09/07/2012 - "This review discusses data regarding the effect of early administration of BCAA granules based on the ratio of BCAA to BTR on prognosis in patients with cirrhosis." 05/07/2012 - "BTR correlates with various liver function examinations, including markers of hepatic fibrosis, hepatic blood flow and hepatocyte function, and can thus be considered as reflecting the degree of hepatic impairment. " 05/01/2011 - "In all, 134 patients with cirrhosis of common etiologies treated at the Liver Research Institute, University of Arizona, between May 2008 and July 2009, and 528 healthy subjects were screened for variation in the TERT and TERC genes by direct sequencing; an additional 1,472 controls were examined for the most common genetic variation observed in patients. " 09/01/2003 - "In conclusion, decrease of blood flow through liver and increase in porto-systemic shunt might be partly responsible for deterioration of BTR in early cirrhosis."
4.	Uterine Cervical Dysplasia 01/01/2014 - "hTERC gene overexpression could prognoses cervical intraepithelial neoplasia 1 natural prognosis individually." 01/01/2014 - "Prospective study of hTERC gene detection by fluorescence in situ hybridization (FISH) in cervical intraepithelial neoplasia 1 natural prognosis." 08/21/2012 - "The detection of hTERC amplification using fluorescence in situ hybridization in the diagnosis and prognosis of cervical intraepithelial neoplasia: a case control study." 05/01/2012 - "Gain of human telomerase RNA gene is associated with progression of cervical intraepithelial neoplasia grade I or II." 04/13/2012 - "Genomic amplification patterns of human telomerase RNA gene and C-MYC in liquid-based cytological specimens used for the detection of high-grade cervical intraepithelial neoplasia."
5.	Uterine Cervical Neoplasms (Cancer of the Cervix) 06/01/2013 - "The negative predictive value of both HPV L1 and hTERC was higher than that of HPV L1 or hTERC, but there was no marked difference in the screening efficacy of cervical cancer among HPV L1, hTERC and HPV L1+hTERC. " 01/01/2015 - "Despite the limitation of a small study sample, our findings provide promising data, indicating the possible role of hTERC analysis in the assessment of the risk of developing cervical cancer. " 07/01/2011 - "The present study highlights the importance of using hTERC and C-MYC genes FISH probes for cases with cancer cervix or pre-malignant lesions as a sensitive technique. " 05/01/2020 - "Relevance research between the expression of p16INK4a , Notch1, and hTERC genes: The development of HPV16-positive cervical cancer." 11/04/2019 - "In conclusion, hTERC is a potential marker for precancerous cervical cancer lesions. "

Related Drugs and Biologics

1.	Serum Albumin
2.	Telomerase (Telomerase Reverse Transcriptase)
3.	Branched-Chain Amino Acids
4.	Glucose (Dextrose)
5.	Interferon-alpha (Interferon Alfa)
6.	Gal-VP16
7.	tumor-associated transplantation antigen (TSTA)
8.	telomerase RNA (bTR)
9.	Messenger RNA (mRNA)
10.	Tyrosine (L-Tyrosine)

Related Therapies and Procedures

1.	Blepharoplasty
2.	Therapeutics
3.	Transplantation
4.	Heart-Assist Devices
5.	Drug Therapy (Chemotherapy)