HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

ER 076349

structure in first source

Also Known As:

ER-076349; ER-76349

Networked: 4 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - ER 076349: 4

Experts

1.	Littlefield, Bruce A: 2 articles (01/2011 - 07/2008)
2.	Aalfs, Kimberley K: 1 article (01/2011)
3.	Kishi, Yoshito: 1 article (01/2011)
4.	Lewis, Bryan M: 1 article (01/2011)
5.	Salvato, Kathleen A: 1 article (01/2011)
6.	Seletsky, Boris M: 1 article (01/2011)
7.	Towle, Murray J: 1 article (01/2011)
8.	Wels, Bruce F: 1 article (01/2011)
9.	Yu, Melvin J: 1 article (01/2011)
10.	Zheng, Wanjun: 1 article (01/2011)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2008 - "We also examined a more potent, but in tumors less efficacious antiproliferative halichondrin derivative, ER-076349. " 01/15/2011 - "Eribulin (E7389), a mechanistically unique microtubule inhibitor in phase III clinical trials for cancer, exhibits superior efficacy in vivo relative to the more potent compound ER-076349, a fact not explained by different pharmacokinetic properties. " 08/25/2009 - "Eribulin is currently undergoing phase III clinical trials for cancer; ER-076349 is a closely related analogue with C.35 hydroxyl instead of C.35 primary amine [Towle, M. " 02/01/2001 - "In this study, we show that two macrocyclic ketone analogues of halichondrir B, ER-076349 and ER-086526, have sub-nM growth inhibitory activities in vitro against numerous human cancer cell lines as well as marked in vivo activities at 0.1-1 mg/kg against four human xenografts: MDA-MB-435 breast cancer, COLO 205 colon cancer, LOX melanoma, and NIH: OVCAR-3 ovarian cancer. "
2.	Ovarian Neoplasms (Ovarian Cancer) 02/01/2001 - "In this study, we show that two macrocyclic ketone analogues of halichondrir B, ER-076349 and ER-086526, have sub-nM growth inhibitory activities in vitro against numerous human cancer cell lines as well as marked in vivo activities at 0.1-1 mg/kg against four human xenografts: MDA-MB-435 breast cancer, COLO 205 colon cancer, LOX melanoma, and NIH: OVCAR-3 ovarian cancer. "
3.	Melanoma (Melanoma, Malignant) 02/01/2001 - "In this study, we show that two macrocyclic ketone analogues of halichondrir B, ER-076349 and ER-086526, have sub-nM growth inhibitory activities in vitro against numerous human cancer cell lines as well as marked in vivo activities at 0.1-1 mg/kg against four human xenografts: MDA-MB-435 breast cancer, COLO 205 colon cancer, LOX melanoma, and NIH: OVCAR-3 ovarian cancer. "
4.	Colonic Neoplasms (Colon Cancer) 02/01/2001 - "In this study, we show that two macrocyclic ketone analogues of halichondrir B, ER-076349 and ER-086526, have sub-nM growth inhibitory activities in vitro against numerous human cancer cell lines as well as marked in vivo activities at 0.1-1 mg/kg against four human xenografts: MDA-MB-435 breast cancer, COLO 205 colon cancer, LOX melanoma, and NIH: OVCAR-3 ovarian cancer. "
5.	Breast Neoplasms (Breast Cancer) 02/01/2001 - "In this study, we show that two macrocyclic ketone analogues of halichondrir B, ER-076349 and ER-086526, have sub-nM growth inhibitory activities in vitro against numerous human cancer cell lines as well as marked in vivo activities at 0.1-1 mg/kg against four human xenografts: MDA-MB-435 breast cancer, COLO 205 colon cancer, LOX melanoma, and NIH: OVCAR-3 ovarian cancer. "

Related Drugs and Biologics

1.	eribulin
2.	Hydroxyl Radical
3.	Ketones
4.	Amines