|1.||Yoshida, Daizo: 6 articles (05/2004 - 01/2002)|
|2.||Teramoto, Akira: 6 articles (05/2004 - 01/2002)|
|3.||Takahashi, Hiroshi: 5 articles (05/2004 - 01/2002)|
|4.||Sugisaki, Yuichi: 4 articles (01/2004 - 01/2002)|
|5.||Watanabe, Kunihiro: 4 articles (01/2003 - 01/2002)|
|6.||Noha, Masahiro: 4 articles (01/2003 - 01/2002)|
|7.||Okuyama, A: 2 articles (08/2001 - 04/2001)|
|8.||Yoshida, D: 2 articles (01/2001 - 07/2000)|
|9.||Watanabe, K: 2 articles (01/2001 - 07/2000)|
|10.||Teramoto, A: 2 articles (01/2001 - 07/2000)|
03/01/2002 - "The angiogenesis promoted by glioma supernatants showed a significant reduction in the presence of SI-27 (10 micromol/L; U87MG, P < 0.01; U251MG, P < 0.01; U373MG, P < 0.01). "
01/01/2001 - "The angiogenesis promoted by glioma supernatants showed a significant reduction in the presence of SI-27. "
05/01/2004 - "Systemic administration of the anti-MMP agent SI-27 is effective in the treatment of glioma in an animal model."
01/01/2004 - "Drug-induced apoptosis by a matrix metalloproteinase inhibitor, SI-27 on human malignant glioma cell lines; in vitro study."
07/01/2000 - "In this study, we employed a novel MMP inhibitor, SI-27 to investigate inhibition of cell invasiveness in human malignant glioma cell lines, U87MG, U251MG, and U373MG. "
03/01/2002 - "This study was designed to investigate the suppression of tumor angiogenesis by SI-27, an MMP inhibitor. "
01/01/2001 - "The current study aimed for a novel approach to in vitro assay of angiogenesis with a "wet scanning electron microscope (SEM)" to investigate suppression of tumor angiogenesis by the MMP inhibitor, SI-27. "
01/01/2003 - "To allow the quantitative assessment of tumor cell invasion, the invasion area index was measured on Days 1, 3, 5, and 7 with a fluorescence stereomicroscope and an image analyzer in the presence of various concentrations of SI-27 (0, 1, 10, 50, or 100 microg/ml). "
03/01/2002 - "SI-27 inhibited in vitro tumor angiogenesis by suppression of MMP. "
01/01/2002 - "To allow quantitative assessment of tumor cell invasion, the invasion area index was measured on days 1, 3, 5, and 7 by a fluorescence stereomicroscope and an image analyzer in the presence of varying concentrations of SI-27. "
|3.||Hematologic Neoplasms (Hematological Malignancy)
|5.||Myeloid Leukemia (Leukemia, Myelocytic)
08/01/2001 - "A new matrix metalloproteinase inhibitor SI-27 induces apoptosis in several human myeloid leukemia cell lines and enhances sensitivity to TNF alpha-induced apoptosis."
08/01/2001 - "SI-27 alone induces apoptosis in several human myeloid leukemia cell lines such as U937, NB4, and HL60 cells by activating caspase 8, 9, and 3. Apoptosis was measured with annexin V positive staining, a drop in mitochondrial transmembrane potential (deltapsim), presence of hypodiploid DNA, and cleavage of PARP and IkappaBalpha. "
|1.||Tissue Inhibitor of Metalloproteinase-1
|3.||Caspase 8 (Caspase-8)
|4.||Insulin-Like Growth Factor Binding Protein 3
|6.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|8.||Insulin-Like Growth Factor I (IGF-1)
|10.||DNA (Deoxyribonucleic Acid)