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rhinacanthone

structure in first source

Also Known As:

3,4-dihydro-3,3-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kongkathip, Ngampong: 2 articles (07/2009 - 07/2003)
2.	Siripong, Pongpun: 2 articles (07/2009 - 07/2003)
3.	Horii, Haruka: 1 article (02/2013)
4.	Sakagami, Hiroshi: 1 article (02/2013)
5.	Shirataki, Yoshiaki: 1 article (02/2013)
6.	Suzuki, Ryuichiro: 1 article (02/2013)
7.	Tomomura, Akito: 1 article (02/2013)
8.	Tomomura, Mineko: 1 article (02/2013)
9.	Kma, Lakhan: 1 article (01/2013)
10.	Hahnvajanawong, Chariya: 1 article (07/2009)

Related Diseases

1.	Neoplasms (Cancer) 07/17/2003 - "Rhinacanthone (1) and two 1,2-pyranonaphthoquinones (2,3) were synthesized and found to show very potent cytotoxicity against three cancer cell lines (KB, HeLa and HepG(2)) with IC(50) values of 0.92-9.63 microM, whereas the corresponding hydroxylated derivative 4 had reduced cytotoxicity (IC(50) values of 7.61-24.13 microM). " 02/01/2013 - "Among five rhinacanthins (rhinacanthin C, G, N and Q, and rhinacanthone), rhinacanthin C exhibited the highest tumor specificity (TS=15.2). "
2.	Uterine Cervical Neoplasms (Cancer of the Cervix) 07/01/2009 - "Taken together, our findings for the first time demonstrate that rhinacanthone-induced apoptosis in HeLa cells is mediated primarily through the mitochondria-dependent signaling pathway, suggesting that it may be a promising agent for the treatment of human cervical cancer." 01/01/2013 - "dealbata appear promising in different human cervical carcinoma cells with the IC50 of 4.0-8 μg/mL. However, other compounds such as rhinacanthone and neolignans isolated from different plants are not far behind and kill cervical cancer cells at a very low concentrations. "
3.	Carcinoma (Carcinomatosis) 07/01/2009 - "Therefore, we investigated the effects of rhinacanthone on cell proliferation, cell cycle progression and apoptosis induction in human cervical carcinoma (HeLa) cells. " 07/01/2009 - "Induction of apoptosis by rhinacanthone isolated from Rhinacanthus nasutus roots in human cervical carcinoma cells." 01/01/2013 - "dealbata appear promising in different human cervical carcinoma cells with the IC50 of 4.0-8 μg/mL. However, other compounds such as rhinacanthone and neolignans isolated from different plants are not far behind and kill cervical cancer cells at a very low concentrations. "
4.	Lymphoma (Lymphomas) 12/01/2000 - "Antitumour activity of rhinacanthone against Dalton's ascitic lymphoma." 12/01/2000 - "The antitumour activity of Rhinacanthone (3,4-dihydro-3,3-dimethyl-2H-naphtho-[1,2-B] pyran-5,6-dione) has been evaluated against Dalton's ascitic lymphoma (DAL) in Swiss albino mice. "

Related Drugs and Biologics

1.	Lignans
2.	Pyrans
3.	rhinacanthin-C