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HMR 1556

an I(Ks) channel blocker; structure in first source

Also Known As:

(3R,4S)-(+)-N-(3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)chroman-4-yl)-N-methylmethanesulfonamide; chromanol HMR1556

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromans: 3
        HMR 1556: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromans: 3
        HMR 1556: 4
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - HMR 1556: 4
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - HMR 1556: 4

Experts

1.	Gerlach, Uwe: 2 articles (05/2005 - 03/2004)
2.	Backx, P H: 1 article (12/2008)
3.	Dorian, P: 1 article (12/2008)
4.	So, P P-S: 1 article (12/2008)
5.	Bauer, Alexander: 1 article (05/2005)
6.	Becker, Ruediger: 1 article (05/2005)
7.	Katus, Hugo A: 1 article (05/2005)
8.	Kelemen, Kamila: 1 article (05/2005)
9.	Koch, Martin: 1 article (05/2005)
10.	Kraft, Patricia: 1 article (05/2005)

Related Diseases

1.	Atrial Fibrillation 03/01/2004 - "Atrial and ventricular effective refractory periods, sinus node recovery time, Wenckebach cycle-length, atrial fibrillation duration and electrocardiographic intervals were measured before and after intravenous HMR 1556. " 05/01/2005 - "The new selective I(Ks)-blocking agent HMR 1556 restores sinus rhythm and prevents heart failure in pigs with persistent atrial fibrillation." 03/01/2004 - "HMR 1556 reduced vagal atrial fibrillation duration from 1077 +/- 81 to 471 +/- 38 s, an effect abolished by nadolol and greatly potentiated by dofetilide (duration 77 +/- 30 s). " 01/01/2004 - "Selective blockers (chromanol 293B, HMR-1556, L-735,821) of the KvLQT1 plus minK channel, which carriy the slow delayed rectifier potassium current (I(Ks)), were also considered to treat arrhythmias, including atrial fibrillation (AF). "
2.	Torsades de Pointes (Torsade de Pointes) 12/01/2008 - "Slow delayed rectifier K+ current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles."
3.	Heart Failure 05/01/2005 - "Pigs treated with placebo developed high ventricular rates (297 +/- 5 bpm) and severe heart failure, whereas pigs treated with HMR 1556 remained hemodynamically stable. " 05/01/2005 - "The new selective I(Ks)-blocking agent HMR 1556 restores sinus rhythm and prevents heart failure in pigs with persistent atrial fibrillation."

Related Drugs and Biologics

1.	Potassium
2.	Nadolol (Corgard)
3.	L 735821
4.	6- cyano- 4- (N- ethylsulfonyl- N- methylamino)- 3- hydroxy- 2,2- dimethylchromane
5.	dofetilide (Tikosyn)