2- (1H- imidazol- 4- ylmethyl)- 8H- indeno(1,2- d)thiazole

04/03/2003 - "YM-31636 was examined for its effects on defecation in animals, thus evaluating the compound as an agent against constipation."
08/02/2002 - "These results suggest that 5-HT(3) receptor agonists such as YM-31636 are useful in treating constipation since they facilitate GMC-like contractions and defecation without undesired changes in gut motility pattern."
07/20/2001 - "These results suggest that YM-31636 could be promising in the treatment of constipation. "
11/09/2001 - "Consequently, 5-HT3 receptor agonists like YM-31636 would be promising in the treatment of chronic constipation."
07/20/2001 - "We examined the effects of YM-31636 (2-(1H-imidazol-4-ylmethyl)-8H-indeno[1,2-d]thiazole monofumarate), a newly synthesized 5-HT(3) receptor agonist, on defecation in normal and constipated ferrets, and evaluated it as an agent against constipation. "

11/09/2001 - "In conclusion, YM-31636 facilitated defecation without increasing visceral pain. "
11/09/2001 - "In two visceral pain reflex models, YM-31636 neither changed the magnitude of pressor response to colonic distension in anesthetized rats nor affected the visceromotor threshold to colorectal distension in conscious rats. "
11/09/2001 - "We examined the effects of YM-31636 (2-(1H-imidazol-4-ylmethyl)-8H-indeno[1,2-d]thiazole monofumarate), a novel 5-HT3 receptor agonist, on gastrointestinal functions including visceral pain reflex in rats. "

11/09/2001 - "A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain."

12/08/2000 - "In isolated guinea pig right atrium, YM-31636 induced tachycardia with the relative intrinsic activity of approximately 0.23. "

07/20/2001 - "YM-31636 facilitated defecation without inducing diarrhea or emetic episodes. "
07/20/2001 - "This effect occurred within 1 h after oral administration, mostly within 30 min, whereas sodium picosulfate, a widely used laxative, tended to increase the frequency of defecation for several hours with much lower peak incidence than that of YM-31636, and induced diarrhea. "