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PD 168368

a neuromedin B receptor antagonist; structure in first source

Also Known As:

PD168368

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - PD 168368: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - PD 168368: 5

Experts

1.	Bae, Moon-Kyoung: 3 articles (11/2021 - 12/2011)
2.	Bae, Soo-Kyung: 3 articles (11/2021 - 12/2011)
3.	Kim, Mi-Kyoung: 3 articles (11/2021 - 12/2011)
4.	Park, Hyun-Joo: 3 articles (11/2021 - 12/2011)
5.	Kim, Hyung Joon: 2 articles (11/2021 - 09/2016)
6.	Choi, Kyu-Sil: 2 articles (09/2016 - 12/2011)
7.	Kim, Yeon: 1 article (11/2021)
8.	Jeong, Joo-Won: 1 article (09/2016)
9.	Jang, Hye-Ock: 1 article (12/2011)
10.	Kim, Su-Ryun: 1 article (12/2011)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 09/01/2016 - "In the present study, we showed that an NMB-R antagonist, PD168368, suppresses migration and invasion of the human breast cancer cell line MDA-MB-231. " 12/15/2011 - "In addition, PD168368 showed growth inhibitory effects on MDA-MB-231 breast cancer cells by inducing cell cycle arrest and apoptosis. " 09/01/2016 - "Moreover, we found that PD168368 potently inhibits in vivo metastasis of breast cancer. " 12/15/2011 - "Furthermore, PD168368 effectively suppressed tumor growth in a xenograft model of breast tumor in vivo. " 09/01/2016 - "In addition, PD168368 reduced epithelial-mesenchymal transition (EMT) of breast cancer cells by E-cadherin upregulation and vimentin downregulation. "
2.	Neoplasms (Cancer) 10/01/2023 - "Here, we assessed NMB and NMB receptor (NMBR) expression in human corticotroph adenomas and the effects of NMBR antagonist PD168368 on murine and human corticotroph tumors. " 12/15/2011 - "Furthermore, PD168368 effectively suppressed tumor growth in a xenograft model of breast tumor in vivo. " 10/01/2023 - "In mice with tumor xenografts, tumor growth, ACTH and corticosterone were downregulated by PD168368. "
3.	Chronic Renal Insufficiency 11/01/2021 - "PD168368 also attenuated the arterial calcification in cultured aortic rings and in a rat model of chronic kidney disease. "
4.	ACTH-Secreting Pituitary Adenoma 10/01/2023 - "Here, we assessed NMB and NMB receptor (NMBR) expression in human corticotroph adenomas and the effects of NMBR antagonist PD168368 on murine and human corticotroph tumors. " 10/01/2023 - "The effects of PD168368 on hormone secretion and cell proliferation were studied in vitro, in vivo and in seven patient-derived corticotroph adenoma cells. "
5.	Neoplasm Metastasis (Metastasis) 09/01/2016 - "Moreover, we found that PD168368 potently inhibits in vivo metastasis of breast cancer. "

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5.	Hormones (Hormone)
6.	Corticosterone
7.	Adrenocorticotropic Hormone (ACTH)