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PBOX-6

structure in first source

Also Known As:

pyrrolo-1,5-benzoxazepine-6; Carbamic acid, N,N-dimethyl-, 6-(1-naphthalenyl)pyrrolo(2,1-d)(1,5)benzoxazepin-7-yl ester

Networked: 8 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - PBOX-6: 8
  - Azepines: 11
    - Oxazepines: 5
      - PBOX-6: 8

Experts

1.	Campiani, Giuseppe: 8 articles (10/2016 - 09/2004)
2.	Williams, D Clive: 8 articles (10/2016 - 09/2004)
3.	Zisterer, Daniela M: 8 articles (10/2016 - 09/2004)
4.	Lawler, Mark: 6 articles (12/2010 - 09/2004)
5.	Nathwani, Seema-Maria: 3 articles (12/2010 - 01/2010)
6.	Greene, Lisa M: 3 articles (04/2007 - 09/2004)
7.	Butini, Stefania: 2 articles (10/2016 - 02/2014)
8.	Lennon, Jennifer C: 2 articles (10/2016 - 02/2014)
9.	O'Meara, Anne: 2 articles (10/2016 - 02/2014)
10.	Butler, Stephen: 2 articles (08/2010 - 01/2010)

Related Diseases

1.	Neuroblastoma 10/01/2016 - "Finally, we demonstrate the efficacy of PBOX-6 in an in vivo xenograft model of neuroblastoma. " 02/15/2014 - "In this study we examined the ability of two members, PBOX-6 and -15, to exhibit anti-cancer effects in a panel of drug sensitive and MDR neuroblastoma cell lines. " 02/15/2014 - "The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells."
2.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 09/01/2004 - "PBOX-6 overcomes Bcl-2-mediated resistance to apoptosis in chronic myelogenous leukemia (CML) K562 cells by the time- and dose-dependent phosphorylation and inactivation of antiapoptotic Bcl-2 family members Bcl-2 and Bcl-XL. " 04/01/2007 - "STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells."
3.	Neoplasms (Cancer) 02/15/2014 - "In this study we examined the ability of two members, PBOX-6 and -15, to exhibit anti-cancer effects in a panel of drug sensitive and MDR neuroblastoma cell lines. " 11/01/2005 - "Thus, PBOX-6 could be a promising anti-cancer agent for both hormone-dependent and -independent breast cancers."
4.	Breast Neoplasms (Breast Cancer) 11/01/2005 - "In this study, we sought to determine if PBOX-6, a well characterised member of the PBOX series of compounds, is also an effective inhibitor of breast cancer growth. " 11/01/2005 - "The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo."
5.	Carcinoma (Carcinomatosis) 11/01/2005 - "Moreover, intratumoural administration of PBOX-6 (7.5 mg/kg) significantly inhibited tumour growth in vivo in a mouse mammary carcinoma model (p=0.04, n=5, Student's t-test). " 08/01/2010 - "Likewise, resistance to PBOX-6 and -16 was not evident in P-glycoprotein-expressing A2780-ADR cells in comparison with parent human ovarian carcinoma A2780 cells. " 01/01/2010 - "The effects of PBOX-6 and -16 on cancerous cells (chronic myeloid leukaemia K562 cells and ovarian carcinoma A2780 cells) and primary cultured human umbilical vein endothelial cells (HUVECs) were examined by assessing cell proliferation, microtubular organisation, DNA analysis of cell cycle progression and caspase-3/7 activity. "

Related Drugs and Biologics

1.	Imatinib Mesylate (Gleevec)
2.	Caspase 3 (Caspase-3)
3.	Member 1 Subfamily B ATP Binding Cassette Transporter
4.	Carboplatin (JM8)
5.	Estrogen Receptors
6.	Hormones (Hormone)
7.	DNA (Deoxyribonucleic Acid)
8.	Androgens
9.	4- acetoxy- 5- (1- (naphthyl))naphtho(2,3- b)pyrrolo(2,1- d)(1,4)oxazepine