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ZD7349

Also Known As:

ZD 7349; cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg)

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - ZD7349: 1
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - ZD7349: 1

Experts

1.	Alcock, P J: 1 article (08/2000)
2.	Coath, M: 1 article (08/2000)
3.	Dutta, A S: 1 article (08/2000)
4.	Ferguson, R: 1 article (08/2000)
5.	Gellert, P R: 1 article (08/2000)
6.	Gormley, J J: 1 article (08/2000)
7.	Halterman, T: 1 article (08/2000)
8.	Hassall, L: 1 article (08/2000)
9.	Haworth, D: 1 article (08/2000)
10.	Hayward, C F: 1 article (08/2000)

Related Diseases

1.	Hypersensitivity (Allergy) 08/01/2000 - "Many of the peptides like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) (17), cyclo(MeIle-Leu-Asp-Val-D-Arg-D-Arg-D-Phe) (20), cyclo(MeIle-Leu-Asp-Val-D-Arg-D-Arg-MePhe) (21) and cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg-D-Ala-D-Ala) (23) were potent inhibitors of VLA-4-mediated cell adhesion and inhibited ovalbumin-induced delayed type hypersensitivity (DTH) response in mice. "
2.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 08/01/2000 - "or i.v. bolus injection at a dose of 1-10 mg/kg. ZD7349 was also active in type II collagen-induced arthritis (CIA) and experimental autoimmune encephalomyelitis (EAE) tests at a dose of 3-10 mg/kg. The peptide was released from some formulations over a period of 10-20 days. "
3.	Arthritis (Polyarthritis) 08/01/2000 - "or i.v. bolus injection at a dose of 1-10 mg/kg. ZD7349 was also active in type II collagen-induced arthritis (CIA) and experimental autoimmune encephalomyelitis (EAE) tests at a dose of 3-10 mg/kg. The peptide was released from some formulations over a period of 10-20 days. "

Related Drugs and Biologics

1.	ZD7349
2.	Collagen Type II (Type II Collagen)
3.	Peptides (Polypeptides)
4.	Ovalbumin
5.	leucyl-aspartyl-valine
6.	alanylalanine (Ala-Ala)