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isopetasin

inhibits biosynthesis of cysteinyl-leukotriene; from Petasites formosanus Kitamurai; structure in first source

Also Known As:

S-isopetasin

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - isopetasin: 6

Experts

1.	Ko, Wun-Chang: 2 articles (04/2008 - 07/2002)
2.	Lin, Yun-Lian: 2 articles (04/2008 - 07/2002)
3.	Wang, Sheng-Hao: 2 articles (04/2008 - 07/2002)
4.	Abdelfatah, Sara: 1 article (06/2021)
5.	Asensio, Maitane: 1 article (06/2021)
6.	Böckers, Madeleine: 1 article (06/2021)
7.	Efferth, Thomas: 1 article (06/2021)
8.	Fleischer, Edmond: 1 article (06/2021)
9.	Kadioglu, Onat: 1 article (06/2021)
10.	Klinger, Anette: 1 article (06/2021)

Related Diseases

1.	Asthma (Bronchial Asthma) 07/01/2002 - "This finding reveals that S-isopetasin may have benefit in the treatment of asthma." 04/28/2008 - "In conclusion, S-isopetasin may be beneficial as a bronchodilator in the treatment of chronic obstructive pulmonary disease and asthma exacerbations." 04/01/2001 - "We investigated the mechanisms of action of S-petasin and S-isopetasin, from Petasites formosanus Kitamura which is used as a folk medicine for treating hypertension, tumors, and asthma in Taiwan. "
2.	Neoplasms (Cancer) 06/01/2021 - "As isopetasin and S-isopetasin exerted dual roles, first as cytotoxic compounds and then as P-gp inhibitors, we suggested that their P-gp inhibition is part of a larger complex of mechanisms to induce cell death in cancer patients. " 04/01/2001 - "We investigated the mechanisms of action of S-petasin and S-isopetasin, from Petasites formosanus Kitamura which is used as a folk medicine for treating hypertension, tumors, and asthma in Taiwan. " 06/01/2021 - "Isopetasin and S-isopetasin as novel P-glycoprotein inhibitors against multidrug-resistant cancer cells."
3.	Migraine Disorders (Migraine) 04/13/2021 - "Butterbur root extract with its active ingredients petasin and isopetasin has been used in the prophylactic treatment of migraine for years, while its sites of action are not completely clear. " 09/01/2017 - "Here, we investigated the ability of isopetasin, a major constituent of these extracts, to specifically target TRPA1 channel and to affect functional responses relevant to migraine. " 09/01/2017 - "The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel."
4.	Chronic Obstructive Pulmonary Disease (COPD) 04/28/2008 - "In conclusion, S-isopetasin may be beneficial as a bronchodilator in the treatment of chronic obstructive pulmonary disease and asthma exacerbations."
5.	Respiratory Hypersensitivity 04/28/2008 - "Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airway hyperresponsiveness."

Related Drugs and Biologics

1.	isopetasin
2.	petasin
3.	Member 1 Subfamily B ATP Binding Cassette Transporter
4.	Muscarinic Antagonists
5.	Sesquiterpenes
6.	Bronchodilator Agents (Bronchodilators)
7.	TRPA1 Cation Channel

Related Therapies and Procedures

1.	Traditional Medicine (Folk Remedies)