transglutaminase 5

TRANSGLUTAMINASE 5 (TGM5 or TGX) is an 81 kDa protein in human keratinocytes. Distinguish from GAMMA-GLUTAMYLTRANSPEPTIDASE that is involved with glutathione metabolism.

Also Known As:

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Candi, Eleonora: 2 articles (12/2005 - 09/2002)
2.	Melino, Gerry: 2 articles (12/2005 - 09/2002)
3.	Terrinoni, Alessandro: 2 articles (12/2005 - 09/2002)
4.	Franzke, Claus-Werner: 1 article (01/2017)
5.	Kiritsi, Dimitra: 1 article (01/2017)
6.	Pampalakis, Georgios: 1 article (01/2017)
7.	Sotiropoulou, Georgia: 1 article (01/2017)
8.	Valari, Manthoula: 1 article (01/2017)
9.	Zingkou, Eleni: 1 article (01/2017)
10.	Berns, Adam: 1 article (04/2016)

Related Diseases

1.	acral type Peeling skin syndrome 01/01/2017 - "Enhanced Proteolytic Activities in Acral Peeling Skin Syndrome: A Role of Transglutaminase 5 in Epidermal Homeostasis." 11/01/2014 - "Acral peeling skin syndrome (APSS) is a rare skin fragility disorder usually caused by mutations in the transglutaminase 5 gene (TGM5). " 03/19/2012 - "Acral peeling skin syndrome is a rare autosomal recessive genodermatosis due to a missense mutation in transglutaminase 5. The skin peeling occurs at the separation of the stratum corneum from the stratum granulosum. " 12/01/2005 - "A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome."
2.	Lamellar Ichthyosis (Harlequin Ichthyosis) 09/01/2002 - "We evaluated transglutaminase 5 expression in comparison with proliferating (keratin 14) and differentiating (transglutaminase 3) markers in different diseases, such as psoriasis, ichthyosis vulgaris, lamellar ichthyosis, and Darier's disease. "
3.	Ichthyosis Vulgaris (Dominant Ichthyosis Vulgaris) 09/01/2002 - "We evaluated transglutaminase 5 expression in comparison with proliferating (keratin 14) and differentiating (transglutaminase 3) markers in different diseases, such as psoriasis, ichthyosis vulgaris, lamellar ichthyosis, and Darier's disease. "
4.	Psychotic Disorders (Schizoaffective Disorder) 04/01/2016 - "Structured interviews, cognition, symptoms and life course features were assessed in 48 ethnically-diverse cases with psychosis who underwent targeted exome sequencing of PTPRG (Protein Tyrosine Phosphatase, Receptor Type G), SLC39A13 (Solute Carrier Family 39 (Zinc Transporter) Member 13), TGM5 (transglutaminase 5) and ARMS/KIDINS220 (Ankyrin repeat-rich membrane spanning protein or Kinase D-Interacting Substrate of 220kDa). "
5.	Psoriasis (Pustulosis Palmaris et Plantaris) 09/01/2002 - "We observed that transglutaminase 5 contributes, as a secondary effect, to the hyperkeratotic phenotype in ichthyosis (both vulgaris and lamellar) and in psoriasis. " 09/01/2002 - "We evaluated transglutaminase 5 expression in comparison with proliferating (keratin 14) and differentiating (transglutaminase 3) markers in different diseases, such as psoriasis, ichthyosis vulgaris, lamellar ichthyosis, and Darier's disease. "

Related Drugs and Biologics

1.	Class 5 Receptor-Like Protein Tyrosine Phosphatases
2.	Keratin-14 (Keratin 14)
3.	Proteasome Endopeptidase Complex (Proteasome)
4.	Proteins (Proteins, Gene)
5.	Transglutaminases
6.	Phosphotransferases (Kinase)
7.	Phosphatidate Phosphatase
8.	zinc-binding protein (zinc binding protein)