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buddlejasaponin IV

a triterpenoid saponin from the roots of Bupleurum rigidum; structure in first source

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - buddlejasaponin IV: 7
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - buddlejasaponin IV: 7

Experts

1.	Park, Kwang-Kyun: 3 articles (12/2013 - 06/2007)
2.	Park, Hee-Juhn: 3 articles (10/2011 - 05/2006)
3.	Chung, Won-Yoon: 2 articles (12/2013 - 10/2011)
4.	Hwang, Young Sun: 2 articles (12/2013 - 10/2011)
5.	Lee, Kyung-Tae: 2 articles (06/2007 - 05/2006)
6.	Kim, Ki-Rim: 1 article (12/2013)
7.	Kim, Eun-Cheol: 1 article (10/2011)
8.	Kim, Jin: 1 article (10/2011)
9.	Bonesi, Marco: 1 article (07/2009)
10.	Conforti, Filomena: 1 article (07/2009)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 01/01/2023 - "In the present study, the chemopreventive activity of buddlejasaponin IV (BS‑IV), isolated from the aerial part of Pleurospermum kamtschaticum, was investigated using cell viability, DNA fragmentation, caspase‑3 activity, anoikis, cell adhesion, and flow cytometry assays and a murine lung metastasis model. "
2.	Neoplasms (Cancer) 10/01/2011 - "Buddlejasaponin IV (BS-IV), a major component of Pleurospermum kamtschaticum, exerts antiinflammatory and cytotoxic effects against cancer cells. " 12/01/2013 - "Buddlejasaponin IV (BS-IV), a triterpene saponin isolated from Pleurospermum kamtschaticum HOFFMANN (Umbelliferae), is known to have potent anti-inflammatory activity and cytotoxicity against diverse cancer cell lines. " 07/01/2009 - "Three triterpene saponins isolated from the roots of Physospermum verticillatum and identified as saikosaponin a (1), buddlejasaponin IV (2), and songarosaponin D (3) were investigated in vitro for their cytotoxic activity against a panel of seven different cancer cell lines including ACHN, C32, Caco-2, COR-L23, A375, A549, and Huh-7D12 cell lines. "
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2023 - "Buddlejasaponin IV induces apoptotic cell death by activating the mitochondrial‑dependent apoptotic pathway and reducing α2β1 integrin‑mediated adhesion in HT‑29 human colorectal cancer cells."
4.	Mouth Neoplasms (Oral Cancer) 12/01/2022 - "Anticancer effect of buddlejasaponin IV and buddlejasaponin IVa from Clinopodium umbrosum on oral cancer cells (HN-5)." 12/01/2022 - "umbrosum aerial parts were solvent extracted and extracts were fractionated via various chromatographic techniques, so as to obtain two pure saponins, buddlejasaponin IVa and buddlejasaponin IV. The cytotoxicity activity of the extracts and the two pure compounds on oral cancer cells (HN-5) and human umbilical vein endothelial cells (HUVECs) were investigated by 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) method. "
5.	Inflammation (Inflammations) 05/01/2006 - "The effects of buddlejasaponin IV on acute phase inflammation were studied on serotonin- and carrageenan-induced paw edema. "

Related Drugs and Biologics

1.	Saponins
2.	Triterpenes
3.	Solvents
4.	Serotonin (5 Hydroxytryptamine)
5.	Carrageenan
6.	buddlejasaponin
7.	songarosaponin D
8.	saikosaponin D
9.	thiazolyl blue