|1.||Vainchtein, Liia D: 1 article (04/2010)|
|2.||Schellens, Jan H M: 1 article (04/2010)|
|3.||Beijnen, Jos H: 1 article (04/2010)|
|4.||Rosing, Hilde: 1 article (04/2010)|
|5.||Stubbs, Marion: 1 article (06/2004)|
|6.||Harris, Adrian L: 1 article (06/2004)|
|7.||Troy, Helen: 1 article (06/2004)|
|8.||Leach, Martin O: 1 article (06/2004)|
|9.||Griffiths, John R: 1 article (06/2004)|
|10.||Judson, Ian R: 1 article (06/2004)|
06/01/2004 - "(19)F tumor spectra were acquired for determination of rate constants of capecitabine breakdown and buildup and subsequent breakdown of intermediates, 5'-deoxy-5-fluorocytidine (5'DFCR) and 5'DFUR. "
11/01/2002 - "Previous studies have shown that CAP activation follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouridine (5'-DFUR), to form 5-FU preferentially in tumor tissues. "
07/01/1999 - "It is administrated orally and after absorption it is first metabolized to 5'-deoxy-5-fluorocytidine (5'-DFCR) by carboxylesterase from the liver and then converted to 5'-deoxy-5-fluorouridine (5'-DFUR) by cytidine deaminase from the liver and tumor tissues. "
04/01/2010 - "A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma."
12/01/1999 - "The first step is the conversion to 5'-deoxy-5-fluorocytidine (5'-DFCR) by carboxylesterase located in the liver, then to 5'-deoxy-5-fluorouridine (5'-DFUR) by cytidine deaminase highly expressed in the liver and various solid tumors, and finally to 5-FU by thymidine phosphorylase (dThdPase) preferentially located in tumor tissues. "
|2.||Neoplasm Metastasis (Metastasis)
03/10/2003 - "Microdialysis probes were inserted into a cutaneous metastasis and subcutaneous connective tissue to evaluate the interstitial tissue pharmacokinetics of capecitabine and its metabolites 5'-deoxy-5-fluorocytidine (DFCR), 5'-deoxy-5-fluorouridine (DFUR), and FU by capillary electrophoresis. "
|3.||Liver Diseases (Liver Disease)
|4.||Carboxylesterase (Hydrolase S)