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MGS 0008

a group II mGluR agonist; structure in first source

Also Known As:

2-AFH-CA; 2-amino-3-fluoro bicyclo(3.1.0)hexane-2,6-dicarboxylic acid; 2-amino-3-fluorobicyclo(3.1.0)hexane-2,6-dicarboxylic acid; MGS-0008; MGS0008

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Bridged-Ring Compounds: 1
      - Bridged Bicyclo Compounds
        MGS 0008: 2
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - MGS 0008: 2
Polycyclic Compounds: 6
- Bridged-Ring Compounds: 1
  - Bridged Bicyclo Compounds
    - MGS 0008: 2

Experts

1.	Fukasawa, Misako: 2 articles (10/2020 - 10/2019)
2.	Kinoshita, Kohnosuke: 2 articles (10/2020 - 10/2019)
3.	Ochi, Motoki: 2 articles (10/2020 - 10/2019)
4.	Yamaguchi, Jun-Ichi: 2 articles (10/2020 - 10/2019)
5.	Chaki, Shigeyuki: 1 article (10/2020)
6.	Hashihayata, Takashi: 1 article (10/2020)
7.	Hikichi, Hirohiko: 1 article (10/2020)
8.	Marumo, Toshiyuki: 1 article (10/2020)
9.	Miyakoshi, Naoki: 1 article (10/2020)
10.	Nozoe, Akiko: 1 article (10/2020)

Related Diseases

1.

Schizophrenia (Dementia Praecox)

10/01/2020 - "We previously reported that MGS0008 is a selective group II metabotropic glutamate receptor (mGlu2/3 receptor) agonist that is effective in animal models of schizophrenia. "
10/01/2019 - "Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia."
10/01/2019 - "MGS0274 besylate is an ester-based lipophilic prodrug of a metabotropic glutamate (mGlu) 2 and mGlu3 receptor agonist MGS0008 and being developed for the treatment of schizophrenia. "

Related Drugs and Biologics

1.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
2.	Glutamic Acid (Glutamate)
3.	Prodrugs
4.	Esters