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isoaaptamine

structure in first source

Also Known As:

8-methoxy-1-methyl-1H-benzo(de)(1,6)naphthyridin-9-ol

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Naphthyridines: 2
      - isoaaptamine: 7

Experts

1.	Bokemeyer, Carsten: 2 articles (01/2014 - 01/2014)
2.	Dyshlovoy, Sergey A: 2 articles (01/2014 - 01/2014)
3.	Fedorov, Sergey N: 2 articles (01/2014 - 01/2014)
4.	Honecker, Friedemann: 2 articles (01/2014 - 01/2014)
5.	Shubina, Larisa K: 2 articles (01/2014 - 01/2014)
6.	Bakunina, Irina: 1 article (05/2021)
7.	Balabanova, Larisa: 1 article (05/2021)
8.	Ermakova, Svetlana: 1 article (05/2021)
9.	Likhatskaya, Galina: 1 article (05/2021)
10.	Malyarenko, Olesya: 1 article (05/2021)

Related Diseases

1.	Neoplasms (Cancer) 12/15/2006 - "Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity." 01/01/2014 - "In order to explore further the mechanism of action of aaptamine and its derivatives, we studied the effects of aaptamine (1), demethyl(oxy)aaptamine (2), and isoaaptamine (3) on human cancer cell lines and on AP-1-, NF-κB-, and p53-dependent transcriptional activity in murine JB6 Cl41 cells. " 03/01/2004 - "By use of bioassay (murine P388 lymphocytic leukemia cell line) guided isolation procedures, extracts of the Republic of Singapore marine sponge Hymeniacidon sp. were found to contain demethyloxyaaptamine (1) and aaptamine (3) as prominent cancer cell growth inhibitory constituents accompanied by the trace, albeit more active, component isoaaptamine (4). " 05/05/2021 - "These alkaloids showed no direct inhibitory effect on the cancer α-NaGalase; but isoaaptamine (2), 9-demethylaaptamine (3), damirone B (6), and makaluvamine H (7) reduced the expression of the enzyme in the human colorectal adenocarcinoma cell line DLD-1 at 5 μM. "
2.	Mitochondrial Diseases (Mitochondrial Disease) 04/01/2023 - "Overall, isoaaptamine-induced ROS overproduction in mitochondria could cause mitochondrial dysfunction, apoptosis, and autophagy in the GBM cells."
3.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 01/16/2014 - "Activity of aaptamine and two derivatives, demethyloxyaaptamine and isoaaptamine, in cisplatin-resistant germ cell cancer."
4.	Lymphoid Leukemia 03/01/2004 - "By use of bioassay (murine P388 lymphocytic leukemia cell line) guided isolation procedures, extracts of the Republic of Singapore marine sponge Hymeniacidon sp. were found to contain demethyloxyaaptamine (1) and aaptamine (3) as prominent cancer cell growth inhibitory constituents accompanied by the trace, albeit more active, component isoaaptamine (4). "
5.	Glioblastoma (Glioblastoma Multiforme) 04/01/2023 - "Isoaaptamine increases ROS levels causing autophagy and mitochondria-mediated apoptosis in glioblastoma multiforme cells."

Related Drugs and Biologics

1.	aaptamine
2.	demethyloxyaaptamine
3.	Enzymes
4.	Cisplatin (Platino)
5.	Alkaloids
6.	9-demethylaaptamine
7.	makaluvamine H