2,2',4,6,6'-pentachlorobiphenyl

Also Known As:

2,4,6,2',6'-pentachlorobiphenyl; PCB 104; 1,1'-Biphenyl, 2,2',4,6,6'-pentachloro-

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        Polychlorinated Biphenyls: 1778
        2,2',4,6,6'-pentachlorobiphenyl: 4
  - Halogenated Hydrocarbons: 42
    - Chlorinated Hydrocarbons: 240
      - Polychlorinated Biphenyls: 1778
        2,2',4,6,6'-pentachlorobiphenyl: 4
- Dioxins and Dioxin-like Compounds: 5
  - Polychlorinated Biphenyls: 1778
    - 2,2',4,6,6'-pentachlorobiphenyl: 4

Experts

1.	Eum, Sung Yong: 3 articles (06/2006 - 09/2003)
2.	Hennig, Bernhard: 3 articles (06/2006 - 09/2003)
3.	Lee, Yong Woo: 3 articles (06/2006 - 09/2003)
4.	Toborek, Michal: 3 articles (06/2006 - 09/2003)
5.	Choi, Wangsun: 1 article (09/2003)
6.	Robertson, Larry W: 1 article (09/2003)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2006 - "This study indicates that exposure of human microvascular endothelial cells to 2,2',4,6,6'-pentachlorobiphenyl can stimulate transendothelial migration of tumor cells through up-regulation of matrix metalloproteinase (MMP)-3. " 06/10/2004 - "These results indicate that PCB 104 may contribute to tumor metastasis by inducing VEGF overexpression that stimulates endothelial hyperpermeability and transendothelial migration of cancer cells."
2.	Breast Neoplasms (Breast Cancer) 06/10/2004 - "To examine this hypothesis, we elucidated the effects of 2,2',4,6,6'-pentachlorobiphenyl (PCB 104), a representative of highly ortho-substituted non-coplanar PCB congeners, on the endothelial permeability and transendothelial migration of MDA-MB-231 breast cancer cells. " 11/01/1997 - "PCB 104 was found to 1) compete with tritiated 17beta-estradiol (E2) for binding to the mouse uterine estrogen receptor (ER); 2) induce gene expression in MCF-7 human breast cancer cells transiently transfected with the Gal4-human ER chimeric construct (Gal4-HEGO) and the Gal4-regulated luciferase reporter gene (17m5-G-Luc); and 3) increase MCF-7 cell proliferation in a dose-dependent manner. "
3.	Neoplasm Metastasis (Metastasis) 06/10/2004 - "These results indicate that PCB 104 may contribute to tumor metastasis by inducing VEGF overexpression that stimulates endothelial hyperpermeability and transendothelial migration of cancer cells."
4.	Acute Monocytic Leukemia (Acute Monoblastic Leukemia) 09/01/2003 - "In addition, PCB 104 elevated the adhesion of THP-1 cells (a human acute monocytic leukemia cell line) to endothelial cell monolayers. "

Related Drugs and Biologics

1.	Matrix Metalloproteinases (MMPs)
2.	2,2',4,6,6'-pentachlorobiphenyl
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Estrogen Receptors
5.	Luciferases
6.	Estradiol (Delestrogen)