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FR 901469

an antifungal antibiotic from an unidentified fungus No.11243; structure in first source

Also Known As:

FR901469

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - Depsipeptides: 297
      - FR 901469: 3
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Lipopeptides: 626
    - FR 901469: 3
  - Cyclic Peptides: 530
    - Depsipeptides: 297
      - FR 901469: 3
Lipids: 114793
- Lipopeptides: 626
  - FR 901469: 3

Experts

1.	Barrett, David: 1 article (07/2002)
2.	Barrett, D: 1 article (07/2001)
3.	Harada, K: 1 article (07/2001)
4.	Ikeda, F: 1 article (07/2001)
5.	Maki, K: 1 article (07/2001)
6.	Tanaka, A: 1 article (07/2001)
7.	Watabe, E: 1 article (07/2001)
8.	Fujie, A: 1 article (09/2000)
9.	Furuta, T: 1 article (09/2000)
10.	Hashimoto, S: 1 article (09/2000)

Related Diseases

1.	Mycoses (Diseases, Fungus) 07/18/2002 - "In our search for natural products with a broad spectrum of antifungal activity as lead compounds for novel treatments for mycoses, we have isolated echinocandin-type lipopeptide FR901379 and lipopeptidolactone FR901469, as novel water-soluble antifungal agents that inhibit the synthesis of 1,3-beta-glucan, a key component of the fungal cell wall. "
2.	Infections 09/01/2000 - "FR901469 showed excellent efficacy by subcutaneous injection against both Candida albicans and Aspergillus fumigatus in a murine systemic infection mode, with ED50s of 0.32 and 0.2 mg/kg, respectively. "
3.	Candidiasis (Moniliasis) 07/23/2001 - "Compound 14 displayed significantly reduced hemolytic potential at 1mg/mL and a comparable protective effect to FR901469 in a mouse candidiasis model."

Related Drugs and Biologics

1.	Lipopeptides
2.	Echinocandins
3.	Antifungal Agents
4.	lipopeptidolactone
5.	FR 901379
6.	beta-1,3-glucan

Related Therapies and Procedures

1.	Subcutaneous Injections