SU 6656

a c-Src kinase inhibitor; used to probe growth signaling; structure in first source

Also Known As:

2-oxo-3-(4,5,6,7-tetrahydro--1H-indol-2-ylmethylene)-2,3-dihydro-1H-indole-5-sulfonic acid dimethylamide; N,N-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indole-5-sulfonamide; SU-6656; SU6656

Networked: 28 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cao, Li: 1 article (12/2021)
2.	Chen, Yunlin: 1 article (12/2021)
3.	Fan, Jinqi: 1 article (12/2021)
4.	Liu, Yihao: 1 article (12/2021)
5.	Lu, Li: 1 article (12/2021)
6.	Yin, Yuehui: 1 article (12/2021)
7.	Chen, Yaxi: 1 article (01/2021)
8.	Ding, Qiuying: 1 article (01/2021)
9.	Hou, Zhengping: 1 article (01/2021)
10.	Li, Yanping: 1 article (01/2021)

Related Diseases

1.	Inflammation (Inflammations) 09/19/2023 - "Src inhibitor SU6656 attenuated KOdiaPC- induced EC permeability and inflammation, but inhibition of toll-like receptors TLR1, TLR2, TLR4, and TLR6 had no such protective effects. " 01/01/2017 - "Treatment with inhibitors of Src (SU6656) or EGFR (AG1478) reduced EGFR phosphorylation and downstream signaling which resulted in the inhibition of the OVA-induced inflammatory cell influx in bronchoalveolar lavage fluid (BALF), perivascular and peribronchial inflammation, fibrosis, goblet cell hyper/metaplasia and airway hyper-responsiveness. "
2.	Neoplasms (Cancer) 01/01/2014 - "SU6656 also enhanced the antitumor effects of SS1P and HA22 in mouse xenograft tumor models. " 03/15/2006 - "In vivo, SU6656 administered before irradiation significantly enhanced radiation-induced destruction of blood vessels within the tumor windows and enhanced tumor growth delay when administered during fractionated irradiation. " 08/02/2016 - "Our experiments also reveal that this SL interaction can be targeted by small molecule SRC inhibitors, SU6656 and KX2-391, and can be used to improve elimination of human TNBC tumors in a xenograft model. " 07/01/2007 - "Thus, in addition to its utility for the study of megakaryocyte polyploidization, our results show that SU6656 can also induce polyploidy in cells of lymphoid origin, revealing a chemotherapeutic potential for this inhibitor to limit tumor propagation of malignant B cell lymphomas, although not without affecting normal B cells as well." 01/01/2023 - "Src family kinase targeting in head and neck tumor cells using SU6656, PP2 and dasatinib."
3.	Polyploidy 06/01/2012 - "In contrast, SU6656 did not modify p27(Kip1) expression, slightly altered c-Myc levels and generated polyploid multinucleated cells, indicating inhibition of cytokinesis. " 07/01/2005 - "After 6 days in the presence of thrombopoietin and SU6656, the majority of cells became polyploid and started shedding platelet-like fragments. " 07/01/2007 - "Thus, in addition to its utility for the study of megakaryocyte polyploidization, our results show that SU6656 can also induce polyploidy in cells of lymphoid origin, revealing a chemotherapeutic potential for this inhibitor to limit tumor propagation of malignant B cell lymphomas, although not without affecting normal B cells as well." 07/01/2007 - "We show that prolonged exposure of non-Hodgkin's lymphoma (NHL) cell lines to low doses of the Src family protein tyrosine kinases (SFKs) inhibitor SU6656 caused proliferation abrogation as a result of the formation of cells with single multilobed nuclei and several mitotic spindle poles, features similar to polyploid megakaryocytes. " 07/01/2007 - "Human B lymphocytes and non-Hodgkin's lymphoma cells become polyploid in response to the protein kinase inhibitor SU6656."
4.	Anaplastic Thyroid Carcinoma 06/01/2013 - "The aim of the present study was to investigate the influence of SU6656 on cell survival and to assess the role of p21 and PI3K/Akt signaling in cell survival resulting from SU6656 treatment in anaplastic thyroid carcinoma (ATC) cells. "
5.	B-Cell Lymphoma (Lymphoma, B Cell) 07/01/2007 - "Thus, in addition to its utility for the study of megakaryocyte polyploidization, our results show that SU6656 can also induce polyploidy in cells of lymphoid origin, revealing a chemotherapeutic potential for this inhibitor to limit tumor propagation of malignant B cell lymphomas, although not without affecting normal B cells as well."

Related Drugs and Biologics

1.	Toll-Like Receptors (Toll-Like Receptor)
2.	src-Family Kinases
3.	Dasatinib (BMS 354825)
4.	Nicotine
5.	Mecamylamine
6.	Imatinib Mesylate (Gleevec)
7.	nilotinib
8.	Aurora Kinases
9.	Aurora Kinase B
10.	AMP-Activated Protein Kinases