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L 377202

peptide-doxorubicin conjugate activated by prostate-specific antigen

Also Known As:

L-377,202

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Al-Jamal, Wafa T: 2 articles (01/2022 - 01/2019)
2.	Hudoklin, Samo: 2 articles (01/2022 - 01/2019)
3.	Kostevsek, Nina: 2 articles (01/2022 - 01/2019)
4.	Kreft, Mateja E: 1 article (01/2022)
5.	Ma, Guanglong: 1 article (01/2022)
6.	Na, Li: 1 article (01/2022)
7.	Pereira, Sara: 1 article (01/2022)
8.	Kreft, Mateja Erdani: 1 article (01/2019)
9.	Pereira, Sara G T: 1 article (01/2019)
10.	Stuart, Marc C A: 1 article (01/2019)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2019 - "L-377,202 prodrug (Dox-PSA) was in phase I clinical trials for patients with metastatic castration-resistant prostate cancer (mCRPC). " 11/01/2000 - "L-377,202 was approximately 15 times more effective than was conventional doxorubicin at inhibiting the growth of human prostate cancer tumors in nude mice when both drugs were used at their maximally tolerated doses. "
2.	Neoplasms (Cancer) 11/01/2000 - "L-377,202 was approximately 15 times more effective than was conventional doxorubicin at inhibiting the growth of human prostate cancer tumors in nude mice when both drugs were used at their maximally tolerated doses. " 01/01/2022 - "L-377,202 prodrug consists of doxorubicin (Dox) conjugated to a prostate-specific antigen (PSA) peptide substrate that can be cleaved by enzymatically active PSA at the tumor site. " 11/01/2000 - "In the presence of prostate tumor cells secreting prostate-specific antigen, the peptide moiety of this conjugate, L-377,202, was hydrolyzed, resulting in the release of leucine-doxorubicin and doxorubicin, which are both very cytotoxic to cancer cells. "

Related Drugs and Biologics

1.	Prostate-Specific Antigen (Semenogelase)
2.	Prodrugs
3.	Peptides (Polypeptides)
4.	Doxorubicin (Adriamycin)
5.	Leucine (L-Leucine)

Related Therapies and Procedures

1.	Castration