2- (3'- methoxyphenyl)- 6- pyrrolidinyl- 4- quinazolinone

07/01/2014 - "HMJ-38 in nude mice bearing CAL 27 tumor xenografts decreased tumor growth. "
07/01/2014 - "In in vivo experiments, HMJ-38 also efficaciously suppressed tumor volume in a xenotransplantation model. "
06/01/2014 - "In summary, our novel finding provides more information addressing the pharmacological approach of newly synthesized HMJ-38 for further development and therapeutic application in antiangiogenetic effect of cancer chemotherapy. "
07/01/2014 - "We hypothesized that HMJ-38 might sensitize apoptotic death of human oral carcinoma CAL 27 cells in vitro and inhibit xenograft tumor growth in vivo. "
07/01/2014 - "Furthermore, HMJ-38 enhanced caspase-3 gene expression and protein level in xenotransplanted tumors. "

07/01/2014 - "Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: dissections of endoplasmic reticulum stress, mitochondrial dysfunction and tumor xenografts."

07/01/2014 - "This finding might fully support a critical event for HMJ-38 via induction of apoptotic machinery and ER stress against human oral cancer cells."

07/01/2014 - "We hypothesized that HMJ-38 might sensitize apoptotic death of human oral carcinoma CAL 27 cells in vitro and inhibit xenograft tumor growth in vivo. "
07/01/2014 - "Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: dissections of endoplasmic reticulum stress, mitochondrial dysfunction and tumor xenografts."