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4,4a,5,6,7,8,8a,9- octahydro- 5- propyl- 1H- pyrzolo(3,4- g)quinoline

Also Known As:

LY 171555; trans-(-)-4aR-4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline hydrochloride

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - 4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline: 15

Related Diseases

1.	Epilepsy (Aura) 05/01/1991 - "This study employed the pilocarpine model of epilepsy to determine the relative systemic anticonvulsant potencies of five different D-2 agonists in the mouse, and to investigate the site of anticonvulsant action of LY 171555 in the rat's brain following intracerebral microinjection. "
2.	Seizures (Absence Seizure) 07/12/1991 - "After ipsilateral microinjection of 40 pmol LY 171555 focal and generalized kindled seizures were totally blocked in almost 50% of the rats. " 06/01/1994 - "The more selective D3 agonist LY 171555 (0.2 pmol-7.8 nmol) was less potent, and only attenuated pilocarpine-induced seizures at a dose (500 pmol) that would have stimulated accumbens D2 receptors as well. " 03/01/1993 - "LY 171555 similarly increased the latency of seizures induced by focal hippocampal injection of carbachol (100 micrograms), without changing the frequency or the severity. " 05/01/1991 - "D-2 agonists protected mice against pilocarpine-induced seizures in the rank order of potency PHNO greater than pergolide greater than greater than lisuride = LY 171555 much greater than RU 24213, with ED50 values ranging from 0.17 mg/kg for PHNO to greater than 4.5 mg/kg for RU 24213. "
3.	Dyskinesias (Dyskinesia) 09/01/1987 - "LY 171555 induced repetitive movements of head, legs and trunk, but no oral dyskinesia. " 09/01/1987 - "Biperiden (an anticholinergic drug) and LY 171555 (a selective D2 agonist) completely antagonized the dystonia and dyskinesia induced by SCH 23390 as well as raclopride. " 10/01/1993 - "Four 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-exposed parkinsonian monkeys already exhibiting levodopa- and dopamine agonist-induced dyskinesia received selective D-1 agonists ([2,3,4,5-tetrahydro-7-8-dihydroxy-1-phenyl-1-H-3-benzazepine- HCI] (SKF 38393), [(+-)6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro- 1H-3-benzazepine hydrobromide] (SKF 82958), [(1R, 3S)3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6- dihydroxy-1H-2-benzopyran hydrochloride] (A-77636) and [(-)-(6aR)(12bR)-4,6,6a,7,8,12b-hexahydro-7-methyli ndolo (4,3-ab)-phenanthridine] (CY 208-243)) to compare these drugs with selective D-2 agonists (LY 171555, (+)-4-propyl-9- hydroxynaphthoxazine and bromocriptine) and levodopa in terms of antiparkinsonian efficacy and side effects. "
4.	Hypothermia 01/01/1990 - "Colonic temperature was not changed after acute SKF 38393 while acute LY 171555 induced a hypothermia. " 01/01/1989 - "The selective D2 agonist quinpirole (LY 171555) also elicited dose-dependent hypothermia, whereas the selective D1 agonist SKF 38393 had no effect. "
5.	Hypersensitivity (Allergy) 02/01/1995 - "The lesion induced a behavioural hypersensitivity - as manifested in contralateral rotations - to dopaminergic D1 (SKF 38393) or D2 (LY 171555) agonists which was abolished by the graft. " 01/01/1992 - "The lesion induced a behavioural hypersensitivity to dopaminergic agonists and lesioned animals displayed a strong rotation contralateral to the lesion in response to a test dose of the D1 agonist compound SKF 38393 (2.5 mg/kg) or of the D2 agonist LY 171555 (0.15 mg/kg). "

Related Drugs and Biologics

1.	Pilocarpine (Ocusert)
2.	Anticonvulsants (Antiepileptic Drugs)
3.	2,3,4,5- Tetrahydro- 7,8- dihydroxy- 1- phenyl- 1H- 3- benzazepine (SKF 38393)
4.	Dopamine Agonists (Dopamine Agonist)
5.	SCH 23390
6.	CY 208-243
7.	Raclopride
8.	Quinpirole
9.	Cholinergic Antagonists (Anticholinergics)
10.	Cholinergic Agents (Cholinergics)