|1.||Riecken, E O: 3 articles (09/2001 - 06/2000)|
|2.||Ruehl, M: 3 articles (09/2001 - 06/2000)|
|3.||Jia, J D: 3 articles (09/2001 - 06/2000)|
|4.||Schuppan, D: 3 articles (09/2001 - 06/2000)|
|5.||Popov, Yury: 2 articles (12/2009 - 07/2005)|
|6.||Schuppan, Detlef: 2 articles (12/2009 - 07/2005)|
|7.||Cho, J J: 2 articles (09/2001 - 06/2000)|
|8.||Hahn, E G: 2 articles (09/2001 - 06/2000)|
|9.||Bauer, M: 2 articles (09/2001 - 09/2001)|
|10.||Herbst, H: 2 articles (09/2001 - 06/2000)|
12/01/2002 - "When transgene Phex expression, driven by a mouse pro-alpha1(I) collagen gene promoter, was crossed into the Hyp background, it improved the defective mineralization of bone and teeth but failed to correct the hypophosphatemia and altered vitamin D metabolism associated with the disorder. "
|2.||Osteosarcoma (Osteogenic Sarcoma)
09/01/2000 - "Exposure of osteoblast-like osteosarcoma cells or bone marrow-derived primary osteoblasts to either metallic or polymeric particles of phagocytosable sizes resulted in a marked decrease in the steady-state messenger RNA (mRNA) levels of procollagen alpha1[I] and procollagen alpha1[III]. "
08/01/2000 - "The carcinoma cells seem to play a regulatory role, stimulating the synthesis of collagen type I protein in the surrounding stroma by increasing pro-alpha1(I) collagen mRNA translation. "
08/01/2000 - "In one out of five tissue samples from human undifferentiated thyroid carcinomas, pro-alpha1(I) collagen mRNA expression was also found in a small number of tumour cells. "
08/01/2000 - "Several well-characterized cell lines established from undifferentiated thyroid carcinomas, two from tumours included in the present study, expressed both pro-alpha1(I) collagen and prolyl 4-hydroxylase mRNA, and three of these cell lines also synthesized native triple-helical collagen type I. Taken together, these data suggest that stromal fibroblasts are the main producers of collagen type I in anaplastic thyroid tumours. "
06/01/2005 - "In cell-based assays, SB-525334 (1 microM) blocked TGF-beta1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibited TGF-beta1-induced increases in plasminogen activator inhibitor-1 (PAI-1) and procollagen alpha1(I) mRNA expression in A498 renal epithelial carcinoma cells. "
09/01/2001 - "Contrary to procollagen alpha1(I) and TIMP-1, C18 expression remains constant in acute fibrogenesis and is upregulated in biliary fibrosis. "
05/01/2007 - "Seven days after induction of myocardial infarction (MI) and HF in rats we found 2.3-fold and 1.9-fold increase of pulmonary transforming growth factor-beta1 and procollagen alpha1(I) mRNA levels, respectively, and typical morphological characteristics of pulmonary remodeling including interstitial fibrosis and medial thickening of pulmonary arteries. "
04/25/2000 - "Molecular characterization of myocardial fibrosis during hypothyroidism: evidence for negative regulation of the pro-alpha1(I) collagen gene expression by thyroid hormone receptor."
12/14/2009 - "RAGE stimulation with AGE-BSA and CML-BSA did not alter HSC proliferation, apoptosis, fibrogenic signal transduction and fibrosis- or fibrolysis-related gene expression, except for marginal upregulation of procollagen alpha1(I) mRNA by AGE-BSA. "
09/01/2001 - "Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen alpha1(I) and TIMP-1."
|5.||Liver Cirrhosis (Hepatic Cirrhosis)
03/01/2006 - "Here we have further investigated the downstream effects of phagocytosis by studying NADPH oxidase activation and its link to procollagen alpha1 (I) and TGF-beta1 expression in an immortalized human stellate cell line and in several models of liver fibrosis. "
07/01/2005 - "Hepatitis C virus replicon cells release factors that differentially modulate hepatic stellate cell expression of key genes involved in liver fibrosis in a clearly profibrogenic way, up-regulating procollagen alpha1(I) and procollagen alpha1(III) and down-regulating fibrolytic matrix metalloproteinases. "
11/01/2004 - "The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen alpha1(I), TIMP-1 and MMP-2."
07/01/2010 - "The immunomodulatory effects of AM3 led to reduced hepatic fibrogenesis in cirrhotic rats, as shown by decreased area of liver fibrosis, hydroxyproline content and mRNA expression of procollagen alpha1(I). "
|1.||Messenger RNA (mRNA)
|4.||Collagen Type I (Type I Collagen)
|5.||Procollagen-Proline Dioxygenase (Prolyl Hydroxylase)
|6.||Transforming Growth Factor beta1 (TGF beta 1)
|7.||Tissue Inhibitor of Metalloproteinase-1
|8.||Collagen Type III (Type III Collagen)