|1.||Magae, Junji: 8 articles (04/2015 - 04/2002)|
|2.||Chang, Young-Chae: 7 articles (05/2012 - 04/2005)|
|3.||Park, Kwan-Kyu: 4 articles (04/2012 - 07/2005)|
|4.||Ando, Kunio: 4 articles (10/2006 - 04/2002)|
|5.||Jeong, Ji-Hak: 3 articles (04/2012 - 06/2009)|
|6.||Kim, Cheorl-Ho: 3 articles (06/2009 - 07/2005)|
|7.||Furukawa, Chiharu: 3 articles (06/2009 - 04/2005)|
|8.||Nakajima, Hiroo: 3 articles (06/2009 - 04/2005)|
|9.||Kang, Jeong Han: 2 articles (05/2012 - 10/2006)|
|10.||Chang, Hyeun-Wook: 2 articles (04/2012 - 06/2009)|
04/01/2012 - "Ascochlorin, a non-toxic prenylphenol compound derived from the fungus Ascochyta viciae, has been shown recently to have anti-cancer effects on various human cancer cells. "
07/16/2010 - "Thus, we reveal a role for ascochlorin in inhibiting tumor growth via G1 arrest, and identify a novel regulatory mechanism for c-Myc."
07/16/2010 - "Ascochlorin has a broad spectrum of anti-tumor and anti-metastatic activities, but the molecular mechanism by which it inhibits cell cycle progression of cancer cells remains to be elucidated. "
07/16/2010 - "Here, we show that ascochlorin, an isoprenoid antibiotic, is a non-toxic anti-cancer agent that induces G1 arrest via the induction of p21(WAF1/CIP1) in a c-Myc, but not a p53, dependent manner. "
07/01/2005 - "In conclusion, ascochlorin represents a unique natural anti-tumor compound that specifically inhibits MMP-9 activity through suppression of AP-1-dependent induction of MMP-9 gene expression."
|2.||Hypertension (High Blood Pressure)
10/01/2006 - "Ascochlorin reduces serum cholesterol and triglyceride levels, suppresses hypertension and tumor development, and ameliorates type I and II diabetes. "
04/01/2002 - "The prenyl-phenol antibiotics ascochlorin-related compounds, are known to reduce serum cholesterol and triglyceride, suppress hypertension, and ameliorate types-I and II diabetes. "
07/01/2005 - "Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells."
04/01/2012 - "Here, we investigated the effects of ascochlorin on hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression in human epidermoid cervical carcinoma CaSki cells. "
04/01/2012 - "Ascochlorin inhibits growth factor-induced HIF-1α activation and tumor-angiogenesis through the suppression of EGFR/ERK/p70S6K signaling pathway in human cervical carcinoma cells."
11/01/2007 - "Ascochlorin, which suppresses cellular AP-1 activity, selectively kills estrogen receptor-negative human and mouse breast cancer cell lines, and prolongs the survival time of mice implanted with an estrogen receptor-negative mammary carcinoma. "
07/01/2005 - "Here we examined the effect of ascochlorin, a prenyl-phenol anti-tumor compound from the fungus Ascochyta viciae, on the regulation of signaling pathways that control MMP-9 expression in human renal carcinoma (Caki-1) cells. "
|4.||Osteosarcoma (Osteogenic Sarcoma)
06/15/2009 - "Ascochlorin, a prenylphenol antitumor antibiotic, profoundly increases the expression of endogenous p53 by increasing protein stability in the human osteosarcoma cells and human colon cancer cells. "
10/01/2006 - "Proteome analysis of responses to ascochlorin in a human osteosarcoma cell line by 2-D gel electrophoresis and MALDI-TOF MS."
10/01/2006 - "Here, to better understand the mechanisms by which ascochlorin regulates physiological or pathological events and induces responses in the pharmacological treatment of cancer, we performed differential analysis of the proteome of the human osteosarcoma cells U2OS in response to ascochlorin. "
|5.||Hepatocellular Carcinoma (Hepatoma)
04/01/2015 - "Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3."
05/04/2012 - "4-O-carboxymethyl ascochlorin causes ER stress and induced autophagy in human hepatocellular carcinoma cells."
|2.||Phenol (Carbolic Acid)
|4.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|5.||70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
|6.||Matrix Metalloproteinase 9 (Gelatinase B)
|8.||Transcription Factor AP-1 (Transcription Factor AP 1)
|10.||Epidermal Growth Factor (EGF)