ponazuril

06/01/2004 - "Efficacy of ponazuril in vitro and in preventing and treating Toxoplasma gondii infections in mice."
06/01/2006 - "Horses were administered ponazuril, once per day, beginning 7 days before infection (study day 0) and continuing for 28 days postinfection. "
10/01/2023 - "Results support that treatment of breeding birds with 100 mg/kg ponazuril could reduce the shedding of active oocysts and decrease risk of clinical infection in susceptible juveniles."
06/01/2006 - "These results confirm that treatment with ponazuril at 5.0 mg/kg minimizes, but does not eliminate, infection and clinical signs of EPM in horses."
05/30/2003 - "Ponazuril was administered once, by gavage, at day 1, 3, 7, 10, or 14 post-infection (pi). "

12/01/2021 - "Further studies are needed to evaluate the safety and efficacy of ponazuril in sea turtles with coccidiosis."
06/01/2012 - "Ponazuril was not effective at treating besnoitiosis in a naturally infected donkey. "
06/01/2016 - "Ponazuril may have clinical application in the treatment of clinical coccidiosis due to Eimeria species in goats, along with other protozoal infections. "
05/28/2014 - "The aim of this study was to determine the efficacy of ponazuril paste at each of three dosages (dosage 1, 50mg/kg q24 h for 3 days, dogs n=14, cats n=16; dosage 2, 50mg/kg as a single dose, dogs n=13, cats n=25; or dosage 3, 20mg/kg as a single dose, dogs n=16, cats n=23) in shelter-housed dogs (n=43) and cats (n=64) with confirmed coccidiosis. "
06/01/2016 - "Efficacy trials are underway to determine clinical efficacy of ponazuril in the treatment of clinical coccidiosis in goats at 10 mg/kg dosage."

05/01/2020 - "Ponazuril is used for the treatment of equine protozoal myeloencephalitis (EPM). "
01/01/2001 - "It was concluded that oral administration of ponazuril to healthy horses at 5 mg/kg provided concentrations of ponazuril in the CSF that are presumed to be adequate for the treatment of equine protozoal myeloencephalitis (EPM). "
06/01/2006 - "The ability of ponazuril to prevent or limit clinical signs of equine protozoal myeloencephalitis (EPM) after infection with Sarcocystis neurona was evaluated. "
01/01/2001 - "Efficacy of ponazuril 15% oral paste as a treatment for equine protozoal myeloencephalitis."
01/01/2001 - "Ponazuril, a triazine-derivative compound, is proposed as a treatment for equine protozoal myeloencephalitis caused by Sarcocystis neurona. "

06/01/2004 - "The results demonstrate that ponazuril is effective in preventing and treating toxoplasmosis in mice. "
06/01/2004 - "We used outbred female CD-1 mice to determine the efficacy of ponazuril in preventing and treating acute toxoplasmosis. "
06/01/2004 - "Sixty percent of mice treated with 10 mg/kg ponazuril at 6 days after infection and 100% of mice treated with 20 mg/kg or 50 mg ponazuril 6 days after infection and then daily for 10 days were protected from fatal toxoplasmosis. "
06/01/2004 - "One hundred percent of mice treated with 10 or 20 mg/kg ponazuril at 3 days after infection and then daily for 10 days were protected from fatal toxoplasmosis. "
06/01/2004 - "Mice given 10 or 20 mg/kg body weight ponazuril 1 day before infection and then daily for 10 days were completely protected against acute toxoplasmosis. "

10/18/2002 - "Clinically, ponazuril chemotherapy of infected calves--in comparison to non-treated infected animals--reduced symptoms (fever), but no differences were observed between treated and non-treated animals with regard to serum enzymes and metabolites. "