HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

neocryptolepine

isolated from the roots of the African plant Cryptolepis sanguinolenta; structure in first source

Networked: 10 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - neocryptolepine: 10
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - neocryptolepine: 10

Experts

1.	Shaban, Elkhabiry: 3 articles (02/2021 - 11/2017)
2.	Wietrzyk, Joanna: 3 articles (06/2019 - 05/2014)
3.	Świtalska, Marta: 3 articles (06/2019 - 05/2014)
4.	El-Ghlban, Samah: 2 articles (02/2021 - 11/2017)
5.	Inokuchi, Tsutomu: 2 articles (06/2019 - 11/2017)
6.	Wang, Li: 2 articles (06/2019 - 11/2017)
7.	Wang, Ning: 2 articles (06/2019 - 11/2017)
8.	Ahmed, Hytham M A: 1 article (02/2021)
9.	Altwaijry, Najla: 1 article (02/2021)
10.	Attallah, Nashwah G M: 1 article (02/2021)

Related Diseases

1.	Neoplasms (Cancer) 06/05/2019 - "The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel." 01/01/2023 - "The study evaluated the antitumor efficacy of APAN, "synthesized indoloquinoline analog derived from the parent neocryptolepine isolated from the roots of Cryptolepis sanguinolenta", versus the chemotherapeutic drug etoposide (ETO) in Ehrlich solid tumor (EST)-bearing female mice as well as its protective effect against etoposide-triggered hepatic disorders. " 02/01/2021 - "The cell cycle analysis showed that the neocryptolepine analogs extensively increase the aggregation of tumor cells in three phases of the cell cycle (G0/G1, S and G2/M) with the emergence of a hypo-diploid DNA content peak (sub-G1) in the cell cycle experiments, which is a clear-cut for the apoptotic cell population. " 05/06/2014 - "A series of novel amino acid and dipeptide derivatives of neocryptolepine were synthesized and tested for their antimicrobial, antifungal and antiproliferative activity in vitro against cancer cell lines (KB, A549, MCF-7, LoVo) and normal mice fibroblast cells (BALB/3T3). "
2.	Stomach Neoplasms (Stomach Cancer) 01/05/2023 - "The aim of this study was to synthesize a novel neocryptolepine derivative CFNC and explore its potential anti-gastric cancer effect and molecular mechanism. " 01/05/2023 - "CFNC, a neocryptolepine derivative, inhibited the growth of gastric cancer AGS cells by inhibiting PI3K/AKT signaling pathway." 10/07/2022 - "The cytotoxicity of neocryptolepine to gastric cancer cells AGS, MKN45, HGC27, and SGC7901 was not very strong, and it also had certain toxicity to gastric mucosa cells GES-1. " 10/07/2022 - "Design, Synthesis and Biological Evaluation of Neocryptolepine Derivatives as Potential Anti-Gastric Cancer Agents."
3.	Carcinoma (Carcinomatosis) 01/01/2023 - "The current study evaluated the cytotoxic activity of 11(4-Aminophenylamino)neocryptolepine (APAN), a novel derivative of neocryptolepine, on hepatocellular (HepG2) and colon (HCT-116) carcinoma cell lines as well as, the possible molecular mechanism through which it exerts its cytotoxic activity. " 02/01/2021 - "Neocryptolepine (5-methyl-5H-indolo[2,3-b] quinoline) analogs were synthesized and evaluated in vitro and in vivo for their effect versus Ehrlich ascites carcinoma (EAC). "
4.	Colorectal Neoplasms (Colorectal Cancer) 10/13/2023 - "Neocryptolepine derivatives have attracted a lot of attention because of their good cytotoxic activity; however, cytotoxicity studies on colorectal cancer cells are scarce. "
5.	Leukemia 11/12/2017 - "Many of the prepared neocryptolepine derivatives showed submicromolar antiproliferative activity against the human leukemia MV4-11 cell line. " 12/01/2000 - "Cryptolepine, and to a lesser extent neocryptolepine, provoke a massive accumulation of P388 murine leukemia cells in the G2/M phase. " 06/05/2019 - "This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. "

Related Drugs and Biologics

1.	Etoposide (VP 16)
2.	DNA (Deoxyribonucleic Acid)
3.	Dipeptides
4.	Amino Acids
5.	isocryptolepine
6.	quinoline
7.	cryptolepine