|1.||Kharitonenkov, Alexei: 30 articles (10/2015 - 06/2005)|
|2.||Li, Xiaokun: 16 articles (10/2015 - 01/2010)|
|3.||Xu, Aimin: 14 articles (09/2015 - 05/2008)|
|4.||Itoh, Nobuyuki: 12 articles (11/2015 - 10/2009)|
|5.||Kliewer, Steven A: 12 articles (02/2015 - 06/2007)|
|6.||Mangelsdorf, David J: 12 articles (02/2015 - 06/2007)|
|7.||Konishi, Morichika: 11 articles (11/2015 - 10/2009)|
|8.||Villarroya, Francesc: 9 articles (12/2015 - 11/2010)|
|9.||Maratos-Flier, Eleftheria: 9 articles (09/2015 - 06/2007)|
|10.||Lam, Karen S L: 9 articles (12/2014 - 05/2008)|
11/01/2011 - "Future research should seek to clarify whether FGF21 would be beneficial in the management of obesity and its metabolic complications."
03/01/2015 - "FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. "
12/01/2014 - "Calorie restriction results in FGF21 approaching nonobese control levels, suggesting that this intervention is effective in reducing the "nutritional crisis" that appears to underly FGF21 elevation in obesity. "
09/01/2015 - "Even though FGF signaling has been mainly implicated in developmental processes, recent studies have demonstrated that FGF21 is an important regulator of whole body energy expenditure and metabolism, in obesity. "
09/03/2013 - "Here, we studied the effects of LY2405319 (LY), a variant of FGF21, in a randomized, placebo-controlled, double-blind proof-of-concept trial in patients with obesity and type 2 diabetes. "
|2.||Body Weight (Weight, Body)
01/01/2013 - "In a study conducted in obese male cynomolgus monkeys, animals treated with an FGFR1c/β-Klotho bispecific Avimer showed improved metabolic parameters and reduced body weight comparable to the effects seen with FGF21. "
06/01/2014 - "The objectives of this study were to measure plasma FGF21 concentrations in the Siberian hamster, a rodent which undergoes a seasonal cycle of fattening and body weight gain in the long days (LD) of summer, followed by reduction of appetite and fat catabolism in the short days (SD) of winter. "
01/01/2015 - "Treatment of TSCmKO mice with a chemical chaperone that alleviates ER stress reduced FGF21 production in muscle and increased body weight. "
10/07/2014 - "Here we report that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice. "
05/01/2013 - "Functional relevance was evidenced in mice with genetic deletion of FGF21, where GcgR activation failed to induce the body weight loss and lipid metabolism changes observed in WT mice. "
09/01/2013 - "Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice."
04/01/2015 - "These findings suggest that circulating FGF-21 may differ in its association with bone, lean mass and insulin resistance depending on sex and weight status."
04/01/2015 - "The existence of relationships of FGF-21 with musculoskeletal parameters and insulin resistance raises the possibility of crosstalk between these systems. "
03/01/2015 - "However, homeostasis model assessment of insulin resistance (HOMA-IR), visceral ectopic fat, and inflammatory markers were not found as a direct contributor to serum FGF-21 level (p > 0.05). "
02/01/2015 - "Higher circulating FGF21 levels are related to nutritional status and insulin resistance independent of PCOS. "
08/01/2015 - "FGF21 KO mice were subjected to chronic-binge alcohol exposure, and epididymal white adipose tissue lipolysis and liver steatosis were investigated. "
05/01/2015 - "[A prospective study of serum fibroblast growth factor 21 changes in nonalcoholic fatty liver patients]."
03/01/2015 - "Using several strategies, we show that the reversal of simple fatty liver and NASH is mediated by activation of the FGF21 signaling pathway. "
01/01/2015 - "FGF21 protein level increased in liver tissues at an early stage along with steatohepatitis in diabetic OVE26 mice, but decreased in liver tissues later when HCC was developed. "
02/01/2014 - "SIRT1-mediated activation of FGF21 prevents liver steatosis caused by fasting. "
02/01/2014 - "Remarkably, hyperglycemia was completely normalized following FGF21 treatment in LIRKO mice, even though FGF21 did not reduce gluconeogenesis in these animals. "
02/01/2014 - "Thus, FGF21 corrects hyperglycemia in diabetic mice independently of insulin action in the liver by increasing energy metabolism via activation of brown fat and browning of white fat, but intact liver insulin action is required for FGF21 to control hepatic lipid metabolism. "
07/01/2009 - "A large amount of data, predominantly obtained from murine models but also from non-human primates, suggest that FGF21 ameliorates obesity-associated hyperglycemia and hyperlipidemia primarily via effects on adipose tissue and the pancreas. "
10/01/2015 - "We evaluated whether critical illness elevates serum FGF21 concentrations and whether targeting normoglycemia (80-110 mg/dL) with insulin vs tolerating hyperglycemia may lower serum FGF21 by attenuating mitochondrial dysfunction and the ISR. "
02/01/2014 - "Monkeys that maintain normal levels of the FGF21 co-receptor β-klotho in the WAT on HFD were protected toward development of dyslipidemia and hyperglycemia."
|2.||fibroblast growth factor 21
|5.||Sodium Glutamate (Accent)
|6.||Messenger RNA (mRNA)
|7.||Blood Glucose (Blood Sugar)
|8.||Non-alcoholic Fatty Liver Disease
|4.||Highly Active Antiretroviral Therapy (HAART)
|5.||Protein-Restricted Diet (Diet, Protein Restricted)