fibroblast growth factor 21

03/01/2017 - "FGF-21 treatment strongly improved the metabolic parameters and increased insulin sensitivity in HF rats. "
01/01/2016 - "In conclusion, WPJ protected from diet-induced hepatic steatosis and insulin resistance, which was associated with the improved FGF21 resistance and lipid metabolism. "
09/01/2013 - "Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice."
12/29/2009 - "We show here that obese mice with genetically reduced levels of a key hepatic transcriptional coactivator, PGC-1alpha, have improved whole-body insulin sensitivity with increased levels of hepatic and circulating FGF21. "
05/28/2008 - "FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity."

01/01/2022 - "Here, we show that after long-term high fat diet feeding (HFD), circulating FGF21 levels become similarly high in obese wildtype and obesity-resistant UCP1 KO mice, suggesting improved FGF21 sensitivity in UCP1 KO mice. "
01/01/2019 - "Among those browning agents reported recently, FGF21 play as a quite promising candidate for treating obesity for its obvious enhancement of thermogenic capacity in adipocyte and significant improvement of metabolic disorders in both mice and human. "
11/01/2011 - "Future research should seek to clarify whether FGF21 would be beneficial in the management of obesity and its metabolic complications."
01/01/2023 - "Manipulation of the FGF21 pathway has promising potential as a therapeutic for feline obesity. "
12/01/2014 - "Calorie restriction results in FGF21 approaching nonobese control levels, suggesting that this intervention is effective in reducing the "nutritional crisis" that appears to underly FGF21 elevation in obesity. "

02/19/2020 - "Compared with the control group, the body weight of mice in the experimental group was significantly reduced, and the overall homeostasis was improved in mice treated with human FGF21. "
01/01/2013 - "In a study conducted in obese male cynomolgus monkeys, animals treated with an FGFR1c/β-Klotho bispecific Avimer showed improved metabolic parameters and reduced body weight comparable to the effects seen with FGF21. "
09/12/2023 - "Animals with FGF21 treatment displayed a steady, significant lower body weight over 7-month of the study compared to age-matched control mice. "
03/01/2021 - "The aim of this study was to quantify circulating fibroblast growth factor 21 (FGF-21) changes during and immediately after acute exercise and, based on body weight, to identify the subgroups exhibiting the largest response. "
01/01/2016 - "Previous studies have shown the potential of FGF21 and FGF21-like compounds to decrease body weight in mice, non-human primates, and humans; the precise mechanisms of action remain unclear. "

07/20/2023 - "Objective: To detect the therapeutic efficacy of FGF21 analogues on the zebrafish model of non-alcoholic fatty liver disease. "
01/01/2023 - "This study determined the role of liver FGF21 and the mechanisms underlying the protective effects of time-restricted feeding (TRF) in NAFLD. "
12/01/2023 - "In short, Dubosiella, chiefly regulated by FGF21 signaling during exercise training, has been discovered to govern the protective impacts of exercising counter to the development of NAFLD and exhibits a promising treatment target for NAFLD."
01/01/2022 - "Whether succeeded NAFLD recovery is linked with improved FGF21 sensitivity and finally reverted FGF21 resistance was the focus of the present study. "
08/10/2022 - "We observed that recombinant FGF21 improved hepatic steatosis and HIO in the PCB-induced NAFLD/NASH models. "

03/01/2020 - "Data showed that FGF21 was proved to be beneficial for inhibiting inflammation and apoptosis in the LPS- induced Balb/c mice or LPS induced BEAS-2B or THP-1 cells. "
12/01/2019 - "In vitro, TWIST2 overexpression ameliorated hepatocellular steatosis, inhibited inflammation, and improved mitochondrial content and function with a fibroblast growth factor 21 (FGF21)-dependent pattern. "
01/01/2019 - "The purpose of this study was to determine the role of FGF21 in mediating the MR-induced reduction in inflammation. "
01/01/2018 - "In this study, we investigated whether up-regulation of FGF21 affected inflammation and oxidative stress in atherosclerotic rats and whether the Nrf2-signaling pathway was involved in FGF21-mediated effects. "
02/01/2016 - "The aim of the study is to explore the mechanism for FGF21 alleviating inflammation of CIA. "