|1.||Pincus, Matthew R: 3 articles (12/2008 - 09/2004)|
|2.||Alves, Isabel D: 2 articles (08/2014 - 06/2013)|
|3.||Scotto, Kathleen W: 2 articles (02/2014 - 08/2013)|
|4.||Banerjee, Debabrata: 2 articles (02/2014 - 08/2013)|
|5.||Abali, Emine Ercikan: 2 articles (02/2014 - 08/2013)|
|6.||Bertino, Joseph R: 2 articles (02/2014 - 08/2013)|
|7.||Kerrigan, John E: 2 articles (02/2014 - 08/2013)|
|8.||Xie, Xiaoqi: 2 articles (02/2014 - 08/2013)|
|9.||Minko, Tamara: 2 articles (02/2014 - 08/2013)|
|10.||Johnson-Farley, Nadine: 2 articles (02/2014 - 08/2013)|
09/01/2005 - "In conclusion, a significant improvement in the tumor retention of sc(Fv)2 was achieved by administration of penetratin. "
09/01/2005 - "Real-time whole-body imaging of the live animals confirmed improved tumor localization with penetratin without any increase in the uptake by normal tissues. "
08/01/2014 - "A proapoptotic peptide conjugated to penetratin selectively inhibits tumor cell growth."
01/01/2014 - "We show here that this peptide fused to a penetratin motif causes drastic and rapid cell death in several epithelial cancer cell lines. "
06/01/2013 - "An additional potential is the newly discovered anti-tumor activity of certain CPPs, including RW16 (RRWRRWWRRWWRRWRR) which is derived from penetratin and is investigated here. "
03/01/2014 - "Neuroprotection following in vitro ischemia was more variable with all peptides providing some level of neuroprotection (IC50; Arg-9: 6.0 μM, TAT-D: 7.1 μM, penetratin/Pep-1: >10 μM). "
03/01/2014 - "The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures."
|3.||Breast Neoplasms (Breast Cancer)
11/01/2002 - "Two membrane transporters, the 17 amino acid (aa) oligopeptide penetratin derived from the homeodomain of Antennapedia (Ant) and an analogue of the basic domain of TAT (aa 47-57) (TAT-a) from HIV-1, were tested as carriers for a p53 C-terminal peptide (aa 361-382) into human breast cancer cells. "
05/21/2007 - "In this study, we have shown that both Penetratin- and Tat-conjugated G7-18NATE peptides are able to inhibit the proliferation of SK-BR-3, ZR-75-30, MDA-MB-361 and MDA-MB-231 breast cancer cells. "
11/15/2002 - "Here we demonstrate that the first 4-8 N-terminal amino acids of Smac/DIABLO fused to the Drosophila antennapaedia penetratin sequence, a carrier peptide, enhance the induction of apoptosis and long term antiproliferative effects of diverse antineoplastic agents including paclitaxel, etoposide, 7-ethyl-10-hydroxycamptothecin (SN-38), and doxorubicin in MCF-7 breast cancer cells. "
|4.||Small Cell Lung Carcinoma (Small Cell Lung Cancer)
08/01/2013 - "Antitumor and modeling studies of a penetratin-peptide that targets E2F-1 in small cell lung cancer."
08/01/2013 - "The penetratin-peptide (PEP) demonstrated potent in vitro cytotoxic effects against a range of cancer cell lines, particularly against Burkitt lymphoma cells and small cell lung cancer (SCLC) cells. "
|5.||Pancreatic Neoplasms (Pancreatic Cancer)
08/01/2008 - "When linked to a transporter penetratin peptide, these peptides induce reversion of ras-transformed rat pancreatic cancer cells (TUC-3) to the untransformed phenotype. "
09/01/2004 - "We have synthesized the ras-p21 peptides attached to a penetratin leader sequence to enable cell membrane penetration and introduced these peptides into a ras-transformed pancreatic cancer cell line; these peptides, but not an unrelated negative control peptide, cause the cells to undergo complete phenotypic reversion. "
12/01/2008 - "The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells."
|2.||Glutamic Acid (Glutamate)
|3.||Kainic Acid (Kainate)
|7.||Transcription Factors (Transcription Factor)
|10.||3- (2- carboxypiperazin- 4- yl)propyl- 1- phosphonic acid (CPP)
|2.||Drug Therapy (Chemotherapy)