techneticum TC-99M fanolesomab

injectable anti-CD15 MAb for selective radiolabeling of human neutrophils (PMNs); LeuTech is tradename

Also Known As:

99Tc-fanolesomab; 99mTc-fanolesomab; 99mTc-labeled anti-CD15 MAb; LeuTech; Neutrospec; RB-5 IGM; RB5 IGM; TC-99M RB5 IGM; TC99M RB5 IGM; anti-SSEA-1 MAb; monoclonal antibody anti-SSEA-1; techneticum (99MTC) fanolesomab; techneticum TC 99M fanolesomab

Networked: 11 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Drug Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        techneticum TC-99M fanolesomab: 11
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        techneticum TC-99M fanolesomab: 11
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        techneticum TC-99M fanolesomab: 11

Experts

1.	Kipper, S L: 3 articles (05/2001 - 03/2000)
2.	Love, Charito: 2 articles (04/2007 - 11/2003)
3.	Palestro, Christopher J: 2 articles (04/2007 - 11/2003)
4.	Thakur, M L: 2 articles (05/2001 - 03/2000)
5.	Rypins, E B: 2 articles (09/2000 - 03/2000)
6.	Baum, Kenneth: 1 article (09/2007)
7.	Klingensmith, William C: 1 article (09/2007)
8.	Perlman, Daniel: 1 article (09/2007)
9.	Bhargava, Kuldeep K: 1 article (04/2007)
10.	Nichols, Kenneth J: 1 article (04/2007)

Related Diseases

1.	Infections 04/01/2007 - "99mTc-fanolesomab imaging, performed 18-30 h after injection, diagnosed prosthetic vascular graft infection safely and accurately (95%). " 04/01/2007 - "The objectives of this retrospective investigation were to determine the accuracy of 99mTc-fanolesomab, an antigranulocyte antibody, for diagnosing prosthetic vascular graft infection, ascertain optimum imaging times for this indication, and assess safety of this agent. " 04/01/2007 - "Diagnosing prosthetic vascular graft infection with the antigranulocyte antibody 99mTc-fanolesomab." 01/01/2002 - "LeuTech binds to neutrophils in vivo at the infection site. " 05/01/2001 - "LeuTech was injected directly, intravenously, and its efficacy in imaging infection in 46 consecutive patients was determined. "
2.	Appendicitis 02/01/2002 - "This prospective, multicenter, open-label study evaluated the diagnostic efficacy and clinical impact of LeuTech scintigraphy for detecting appendicitis in patients with an equivocal presentation. " 02/01/2002 - "LeuTech is a convenient, safe, rapid, and sensitive imaging test for diagnosis of appendicitis and favorably impacts patient management in adult and pediatric patients with equivocal signs and symptoms." 02/01/2002 - "LeuTech identified 53 of 59 patients with appendicitis (90% sensitivity) and was negative in 122 of 141 patients without appendicitis (87% specificity). " 01/01/2002 - "The US FDA has recommended LeuTech for approval for the diagnosis of appendicitis in patients with equivocal signs and symptoms. " 01/01/2002 - "A BLA with the US FDA for LeuTech has been filed for the diagnosis of equivocal appendicitis. "
3.	Osteomyelitis 01/01/2002 - "LeuTech is also being investigated in Phase II clinical trials for the diagnosis of osteomyelitis in 45 patients at four sites. " 11/01/2003 - "99mTc-fanolesomab is a radiolabeled imaging agent which is being developed by Palatin Technologies for use in the diagnosis of various infections, including appendicitis and osteomyelitis." 01/01/2002 - "LeuTech is planned to be evaluated for the detection of osteomyelitis secondary to joint replacements (such as hip replacement), postoperative abscesses, ulcerative colitis and other intra-abdominal infections (colitis, spleen or urinary tract). "
4.	Intraabdominal Infections 01/01/2002 - "LeuTech is planned to be evaluated for the detection of osteomyelitis secondary to joint replacements (such as hip replacement), postoperative abscesses, ulcerative colitis and other intra-abdominal infections (colitis, spleen or urinary tract). "
5.	Inflammation (Inflammations) 06/01/2006 - "Imaging of infection and inflammation with 99mTc-Fanolesomab."

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Dihydrotachysterol (AT 10)
3.	Immunoglobulin M (IgM)
4.	Monoclonal Antibodies
5.	Radiopharmaceuticals
6.	Technetium (Technetium 99m)

Related Therapies and Procedures

1.	Replacement Arthroplasty
2.	Injections