|1.||Saetre, T: 3 articles (06/2001 - 08/2000)|
|2.||Höiby, E A: 2 articles (06/2001 - 08/2000)|
|3.||Lyberg, T: 2 articles (06/2001 - 08/2000)|
|4.||Egeland, T: 2 articles (06/2001 - 08/2000)|
|5.||Aspelin, T: 2 articles (06/2001 - 08/2000)|
|6.||Lermark, G: 2 articles (06/2001 - 08/2000)|
|7.||Xu, Miao: 1 article (03/2015)|
|8.||Kang, Tiebang: 1 article (03/2015)|
|9.||Liang, Yi: 1 article (03/2015)|
|10.||Feng, Futuo: 1 article (03/2015)|
02/01/1998 - "Thus, AE-ITU restored hepatic arterial blood flow and increased hepatic oxygen consumption in pigs with endotoxemia."
01/01/2001 - "L-NAME in endotoxemia had detrimental effects on liver circulation, while AE-ITU improved liver blood flow and attenuated the late increase in liver enzymes. "
02/01/1998 - "Aminoethyl-isothiourea, a selective inhibitor of inducible nitric oxide synthase activity, improves liver circulation and oxygen metabolism in a porcine model of endotoxemia."
01/01/2001 - "During porcine endotoxemia (lipopolysaccharide (LPS) 1.7 microg kg(-1) x h(-1) i.v. for 6 h), we compared circulatory and morphological changes in the liver induced by two different NO synthase inhibitors (N(G)-nitro-L-arginine methyl ester, L-NAME, 25 mg x kg(-1) i.v. and aminoethyl-isothiourea, AE-ITU, 10 mg x kg(-1) i.v.), both given after 3 h. "
|2.||Septic Shock (Toxic Shock Syndrome)
|3.||Hypotension (Low Blood Pressure)
08/01/2000 - "Six control pigs received AE-ITU 10 mg/kg/hr iv for 5 hrs. Another six animals received half the dose of GAS over 5 hrs. GAS infusion caused a rapid increase in pulmonary, hepatic, and systemic vascular resistance, followed by hypotension with a 90% lethality at 4 hrs. Treatment with AE-ITU increased 4-hr survival in septic animals from 1/8 to 8/8 and 5-hr survival from 0/8 to 5/8, prevented hypotension, and increased urine output. "
08/01/2000 - "In this model of porcine GAS-induced septic shock, which was not associated with enhanced NO production, infusion of the NOS inhibitor AE-ITU prolonged survival, prevented hypotension, and improved cardiac contractility, organ perfusion, and tissue oxygenation. "
03/01/2015 - "In this study, to block the emergence of SLCCs, aminoethyl isothiourea (AET), a compound that clears free radicals and is used to protect patients from radioactive exposure, was used as an agent that maintains genomic stability in combination with mitomycin C (MMC), a commonly used chemotherapeutic drug that damages DNA. "
|5.||Multiple Organ Failure (MODS)
|1.||NG-Nitroarginine Methyl Ester (L-NAME)
|4.||omega-N-Methylarginine (NG Monomethyl L Arginine)
|8.||beta-Aminoethyl Isothiourea (AET)
|9.||Nitric Oxide Synthase (NO Synthase)
|10.||Nitric Oxide (Nitrogen Monoxide)