polyethylene glycol polyethyleneimine nanogel

12/01/2023 - "Taken together, compared with free Dox, the Dox-conjugated nanogel exhibited higher therapeutic efficacy and lower side effects in normal tissues, making it a potential novel nanomedicine for cancer."
09/25/2015 - "Tumor weight and mice weight were investigated to study the targeting antitumor efficacy of nanogel system. "
04/04/2017 - "Systematic studies demonstrated that such an inhibitor-encapsulated nanogel could effectively enhance the accumulation of Dox in resistant cancer cells, thereby revealing significantly higher antitumor activity compared to free Dox molecules. "
02/21/2015 - "X-ray diffraction (XRD) showed an amorphous property of DOX within the nanogel, which was used in this study as a model anti-cancer drug. "
06/15/2010 - "The pH-responsive property of the nanogel at tumor extracellular pH (pH(e)) was characterized in drug-release kinetic studies. "

01/01/2023 - "Meanwhile, with the clearance of ROS, the nanogel can also reduce oxidative stress and alleviate microenvironment inflammation. "
01/01/2021 - "AM2M was composed of macrophage membrane as "shell" and inflammation-responsive nanogel as "yolk". "
03/14/2019 - "A nanogel based oral gene delivery system targeting SUMOylation machinery to combat gut inflammation."
10/24/2017 - "Unlike xenogeneic hCSCs injected in saline, injection of nanogel-encapsulated hCSCs does not elicit systemic inflammation or local T cell infiltrations in immunocompetent mice. "
10/01/2022 - "These results indicate the potential applications of the injectable TD NT core-shell nanogel to attenuate local or systemic inflammation."

10/01/2021 - "In this review, various approaches will be discussed and compared to the newly developed nanogel technology in terms of efficiency and applicability for determining their potential role in combating infections in the biomedical area including implant-associated infections."
12/30/2020 - "Multifunctional nanogel coatings provide a promising antimicrobial strategy against biomedical implant-associated infections. "
02/01/2011 - "The effects of nanogel encapsulation of recombinant NcPDI (recNcPDI) following vaccination of mice by intranasal or intraperitoneal routes and challenge infection with Neospora caninum tachyzoites were investigated. "
01/01/2020 - "The flexible sialylated nanogel efficiently inhibits the influenza A/X31 (H3N2) infection with IC50 values in low picomolar concentrations and also blocks the virus entry into MDCK-II cells."
05/01/2013 - "The efficacy of the nanogel-based PspA nasal vaccine (cCHP-PspA) was tested in murine pneumococcal airway infection models. "

01/01/2015 - "DOX was loaded into nanogel through a sequential dispersion and dialysis approach with a drug loading efficiency of 56.8 wt%, and the laden nanogel (noted as NG/DOX) showed an appropriate hydrodynamic radius of 56.1±3.5 nm. NG/DOX exhibited enhanced or improved maximum tolerated dose on healthy Kunming mice and enhanced intratumoral accumulation and dose-dependent antitumor efficacy toward H22 hepatoma-xenografted mouse model compared with free drug. "
01/01/2017 - "Preparation of a dual cored hepatoma-specific star glycopolymer nanogel via arm-first ATRP approach."
11/01/2013 - "Enhanced drug delivery to hepatocellular carcinoma with a galactosylated core-shell polyphosphoester nanogel."
04/01/2016 - "The fluorescent nanogel was monitored by an in vivo imaging system with hepatoma tumor-bearing mice. "
02/21/2015 - "Thus, we report here a multi-responsive P(ODGal-VCL-MAA) nanogel with a hepatoma-specific targeting ability for anti-cancer drug delivery."

11/03/2016 - "The developed nanogel exhibited a high therapeutic index that improved tumour inhibition effects and reduced system toxicity in a lung cancer mice model. "
05/28/2021 - "Collectively, the pH-responsive nanogel prepared herein could be considered as a potential nanocarrier for CK to improve its antitumor effects against lung cancer."
06/15/2017 - "Results obtained by flow cytometry and confocal fluorescence microscopy shows that nanogel is greatly internalized by non-small cancer lung cells (A549 cells), that overexpress CD44 receptors. "
10/01/2020 - "Effective treatment of drug-resistant lung cancer via a nanogel capable of reactivating cisplatin and enhancing early apoptosis."
05/28/2021 - "Inhibitory Effect of pH-Responsive Nanogel Encapsulating Ginsenoside CK against Lung Cancer."