entecavir

Also Known As:

6H-purin-6-one, 2-amino-1,9-dihydro-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-; 9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)guanine monohydrate; BMS 200475; BMS-200475; BMS-200475-01; BMS-20047501; BMS20047501; Baraclude; SQ-34676; SQ34676; anhydrous entecavir; entecavir hydrate; entecavir monohydrate

Networked: 1718 relevant articles (304 outcomes, 345 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        entecavir: 1718

Experts

1.	Ahn, Sang Hoon: 39 articles (01/2022 - 01/2009)
2.	Hu, Tsung-Hui: 39 articles (01/2022 - 01/2012)
3.	Chen, Chien-Hung: 37 articles (02/2022 - 03/2012)
4.	Hung, Chao-Hung: 34 articles (01/2022 - 03/2012)
5.	Kim, Seung Up: 31 articles (01/2022 - 01/2011)
6.	Lim, Young-Suk: 30 articles (01/2022 - 10/2009)
7.	Lu, Sheng-Nan: 30 articles (01/2022 - 03/2012)
8.	Park, Jun Yong: 30 articles (01/2022 - 01/2009)
9.	Wang, Jing-Houng: 29 articles (01/2022 - 03/2012)
10.	Kim, Do Young: 27 articles (01/2022 - 01/2009)

Related Diseases

1.	Chronic Hepatitis B 05/01/2012 - "Entecavir is an effective treatment for chronic hepatitis B. " 01/01/2010 - "[Entecavir - options and obstacles of an effective treatment for chronic hepatitis B]." 08/01/2011 - "Registration studies showed entecavir (ETV) to be effective and safe in NUC-naïve patients with chronic hepatitis B virus (HBV), but its effectiveness in routine clinical practice is unknown. " 05/01/2014 - "Entecavir (ETV) is effective and safe in patients with chronic hepatitis B in the short term, but its long term efficacy and safety has not been established. " 05/01/2006 - "Entecavir: a new treatment option for chronic hepatitis B."
2.	Hepatitis B 05/01/2016 - "Entecavir, a drug with high potency and genetic barrier against hepatitis B virus, was believed to become very effective in reducing the hepatitis B burden in India. " 07/25/2023 - "In this study, we verified that the combination of GA and Entecavir is more effective than entecavir monotherapy in the treatment of hepatitis B. " 03/01/2008 - "Based on the results of this study, entecavir is likely to be cost-effective in treating hepatitis B patients in China based on the World Health Organization's recommended maximum willingness to pay threshold." 01/01/2014 - "Entecavir is considered a first-line therapeutic option for hepatitis B, due to its demonstrated efficacy in rapidly suppressing the viral load. " 05/01/2013 - "Entecavir is one of the therapeutic options currently available for the management of chronic hepatitis B. "
3.	Fibrosis (Cirrhosis) 01/01/2012 - "Although entecavir has been shown to improve health outcomes in a cost-effective manner in mixed populations of CHB patients, the cost-effectiveness of entecavir has not been evaluated in CHB patients with decompensated cirrhosis. " 03/20/2023 - "Objective: To systematically evaluate the efficacy of live Bifidobacterium preparations combined with entecavir in the treatment of hepatitis B virus-related cirrhosis. " 11/15/2022 - "To observe the safety and efficacy of adjunctive FZHY on the HBV-associated cirrhosis patients who received 2 years of entecavir but still with advanced fibrosis. " 10/01/2017 - "However, little data exists comparing the safety and efficacy of entecavir for the treatment of hepatitis B virus (HBV)-related compensated, and decompensated cirrhosis, respectively. " 03/01/2012 - "[Efficacy of entecavir treatment in hepatitis B virus-related decompensated cirrhosis]."
4.	Infections 09/20/2017 - "Entecavir (ETV) has been shown to be effective in randomized controlled trials in highly selected patients with hepatitis B virus (HBV) infection. " 01/01/2014 - "The high efficacy of entecavir, associated with its safety profile, its high genetic barrier to resistance and its cost-effectiveness, allowed this molecule to become one of the preferred first-line options of treatment to manage HBV infections. " 01/01/2019 - "The aim of this study was to evaluate the safety and efficacy of the combination of entecavir and peginterferon in adults in the IT phase of chronic HBV infection. " 01/01/2021 - "In a meta-analysis of studies of patients with chronic HBV infection, we found that TDF treatment was associated with a significantly lower (20%) risk of HCC than entecavir treatment. " 01/01/2021 - "We performed a systematic review of the MEDLINE, EMBASE, Web of Science, and Cochrane Library from 2010 through 2019 for full-text articles and conference abstracts on studies of effects of TDF vs entecavir in patients with HBV infection. "
5.	Hepatocellular Carcinoma (Hepatoma) 01/01/2015 - "Efficacy of Prophylactic Entecavir for Hepatitis B Virus-Related Hepatocellular Carcinoma Receiving Transcatheter Arterial Chemoembolization." 03/01/2016 - "The aim of this study was to clarify the effects of long-term entecavir treatment on the incidence of hepatocellular carcinoma (HCC). " 02/01/2023 - "CAGE-B and SAGE-B models better predict the hepatitis B virus-related hepatocellular carcinoma after 5-year entecavir treatment than PAGE-B." 11/01/2021 - "We aimed to determine the relationship between non-MVR and hepatocellular carcinoma (HCC) risk in entecavir-treated CHB patients. " 01/01/2020 - "We investigated whether TDF is associated with the deterioration of renal function in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) requiring frequent computed tomography (CT) evaluations and transarterial chemoembolization (TACE) sessions, when compared to entecavir (ETV). "

Related Drugs and Biologics

1.	Lamivudine (Epivir)
2.	Tenofovir (Viread)
3.	Hepatitis B e Antigens
4.	adefovir
5.	Antiviral Agents (Antivirals)
6.	Nucleosides
7.	Telbivudine
8.	lipoarabinomannan (LAM)
9.	adefovir dipivoxil (Hepsera)
10.	Interferons

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Liver Transplantation
4.	Aftercare (After-Treatment)
5.	Transplantation