|1.||Jung, Jae U: 5 articles (02/2014 - 03/2006)|
|2.||Damania, Blossom: 3 articles (11/2015 - 01/2013)|
|3.||West, John A: 3 articles (11/2015 - 01/2013)|
|4.||Jacobs, Sarah R: 3 articles (11/2015 - 01/2013)|
|5.||Dittmer, Dirk P: 3 articles (08/2015 - 05/2003)|
|6.||Citovsky, Vitaly: 3 articles (01/2015 - 03/2010)|
|7.||Seo, Taegun: 3 articles (03/2012 - 09/2002)|
|8.||Wies, Effi: 3 articles (05/2011 - 01/2008)|
|9.||Neipel, Frank: 3 articles (05/2011 - 01/2008)|
|10.||Shin, Young C: 3 articles (07/2009 - 03/2006)|
|1.||Contagious Ecthyma (Orf)
09/01/2000 - "In this study, we have characterized a novel gene, designated vIRF-3, encoded within the previously predicted ORF K10.5 and our newly identified ORF K10. "
09/01/2000 - "Competition gel shift assays demonstrated that SP-1 bound to these two domains, suggesting that the SP-1 binding sites in the vIRF promoter are involved in its transactivation by ORF 50."
09/01/2000 - "The vIRF-3 ORF encodes a 73-kDa protein with homology to cellular IRF-4 and HHV-8-encoded vIRF-2 and K11. "
09/01/2000 - "Analysis of deletions within the vIRF promoter suggested that two sequence domains were important for its transactivation by the ORF 50 protein, both of which included putative SP-1 and AP-1 binding sites. "
04/02/2000 - "The K9 open reading frame (ORF) of KSHV encodes a virus-encoded interferon regulatory factor (vIRF) which functions as a repressor for cellular interferon-mediated signal transduction, and as an oncogene to induce cell growth transformation. "
04/01/2011 - "The focus of this study was to determine the mechanism(s) of vIRF3 oncogenic activity contributing to KSHV-associated lymphoma. "
01/01/2008 - "Thus, vIRF-3 can be seen as a bona fide oncogene of KSHV-associated lymphoma. "
05/01/2003 - "The vIRF-1/K9 clustered with LANA in KS, in contrast to its homologue, vIRF-3/LANA-2, which is transcribed only in KSHV-associated lymphomas. "
01/01/2012 - "In KSHV-infected effusion lymphoma lines, K10.5/vIRF3 and K11/vIRF2 mRNAs are readily detected during latency, whereas K9/vIRF1 and K10/vIRF4 mRNAs are upregulated during reactivation. "
|3.||Bacillary Dysentery (Shigellosis)
05/01/2014 - "Gene disruption studies have validated VirF as a potential target for an anti-virulence therapy to treat shigellosis by determining that VirF is necessary for virulence, but not required for bacterial viability. "
04/01/2010 - "High-throughput screening of the virulence regulator VirF: a novel antibacterial target for shigellosis."
09/01/2013 - "Distinct roles of Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factors in inflammatory response and cancer."
05/01/2013 - "These data implicate vIRF3 as a critical determinant of the MHC-II antigen presentation function in KSHV-associated PELs that is likely to be important in the pathogenesis of these tumors."
03/18/2010 - "When expressed in Agrobacterium and exported into the plant cell, VBF functionally complements tumor formation by a strain lacking VirF. "
07/01/2009 - "Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway."
01/01/2006 - "Here, we report that double mutation of virF and virE3 leads to strongly diminished tumor formation on tobacco, tomato and sunflower. "
08/04/2015 - "Moreover, the depletion of vIRF1 in the context of KSHV infection prevented efficient viral reactivation and replication, and increased the host IFN response to KSHV. "
03/01/2012 - "Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection."
02/01/2012 - "To assess the role of vIRFs during de novo infection, we have utilized the bacterial artificial chromosome clone of wild-type RRV(17577) (WT(BAC) RRV) to generate a recombinant virus with all 8 of the vIRFs deleted (vIRF-ko RRV). "
05/01/2008 - "The distribution and persistence of pathogenic, virF/lcrF-positive Yersinia pseudotuberculosis were investigated in pigs and in the pig house environment during rearing to determine possible contamination routes of early infections. "
08/01/2007 - "Here, we report a novel immune evasion mechanism of KSHV vIRF3 to block cellular IRF7-mediated innate immunity in response to viral infection. "
|1.||viral interferon regulatory factors
|3.||Proteins (Proteins, Gene)
|4.||DNA (Deoxyribonucleic Acid)
|7.||Interferon Type I
|9.||Toll-Like Receptor 3
|10.||Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)